VHS40367

• Gene Symbol: TP53
• Gene Name: tumor protein p53
• Gene Aliases: BCC7, LFS1, P53, TRP53
• Chromosome Location: Chr.17: 7668402 - 7687550 on Build GRCh38
• UniGene ID: Hs.437460
• Species: Human
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: TP53
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_000546.5	NP_000537.3	7, 8	991
	NM_001126112.2	NP_001119584.1	7, 8	988
	NM_001126113.2	NP_001119585.1	7, 8	991
	NM_001126114.2	NP_001119586.1	7, 8	991
	NM_001126115.1	NP_001119587.1	3, 4	671
	NM_001126116.1	NP_001119588.1	3, 4	671
	NM_001126117.1	NP_001119589.1	3, 4	671
	NM_001126118.1	NP_001119590.1	6, 7	1108
	NM_001276695.1	NP_001263624.1	7, 8	991
	NM_001276696.1	NP_001263625.1	7, 8	991
	NM_001276697.1	NP_001263626.1	3, 4	671
	NM_001276698.1	NP_001263627.1	3, 4	671
	NM_001276699.1	NP_001263628.1	3, 4	671
	NM_001276760.1	NP_001263689.1	7, 8	991
	NM_001276761.1	NP_001263690.1	7, 8	988
GenBank mRNA	AB082923.1	-	7, 8	852
	AF307851.1	-	7, 8	924
	AK223026.1	-	1, 2	84
	AK225838.1	-	7, 8	929
	AK297462.1	-	8, 9	856
	AK297927.1	-	8, 9	901
	AK312568.1	-	7, 8	933
	AM076970.1	-	6, 7	756
	AM076972.1	-	6, 7	789
	AY429684.1	-	6, 7	789
	BC003596.1	-	7, 8	909	3544714
	BT019622.1	-	6, 7	789
	DQ186648.1	-	7, 8	921
	DQ186649.1	-	7, 8	921
	DQ186650.1	-	3, 4	667
	DQ186651.1	-	3, 4	667
	DQ186652.1	-	3, 4	667
	DQ191317.1	-	7, 8	978
	DQ286964.1	-	7, 8	923
	EF101867.1	-	6, 7	756
	EF101868.1	-	6, 7	789
	FJ207420.1	-	7, 8	924
	JN214348.1	-	6, 7	834
	JN601513.1	-	6, 7	789
	JN601514.1	-	6, 7	789
	JN601515.1	-	6, 7	789
	JN601516.1	-	7, 8	763
	JN900492.1	-	6, 7	1097
	JQ026207.1	-	6, 7	779
	JQ026208.1	-	6, 7	784
	JQ026209.1	-	6, 7	794
	JQ694049.1	-	6, 7	812
	JQ694050.1	-	6, 7	812
	JQ694051.1	-	6, 7	812
	KC820708.1	-	3, 4	284
	KC820709.1	-	3, 4	284
	KC820710.1	-	3, 4	284
	KC820711.1	-	3, 4	284
	KC820712.1	-	3, 4	284
	KC820713.1	-	3, 4	284
	KC820714.1	-	3, 4	284
	KC820715.1	-	3, 4	284
	KC820716.1	-	3, 4	284
	KC820717.1	-	3, 4	284
	KC820718.1	-	3, 4	284
	KC820719.1	-	3, 4	284
	KC820720.1	-	3, 4	284
	KC820721.1	-	3, 4	284
	KC820722.1	-	3, 4	284
	KC820723.1	-	3, 4	284
	KC820724.1	-	3, 4	284
	KC820725.1	-	3, 4	284
	KC820726.1	-	3, 4	284
	KC820727.1	-	3, 4	284
	KC820728.1	-	3, 4	284
	KC820729.1	-	3, 4	284
	KC820730.1	-	3, 4	284
	KC820731.1	-	3, 4	284
	KC820732.1	-	3, 4	284
	KC820733.1	-	3, 4	284
	KC820734.1	-	3, 4	284
	KC820735.1	-	3, 4	284
	KC820736.1	-	3, 4	284
	KC820737.1	-	3, 4	284
KC820738.1	-	3, 4	284
KC820740.1	-	3, 4	284
KC820741.1	-	3, 4	284
KC820742.1	-	3, 4	284
KC820743.1	-	3, 4	284
KC820744.1	-	3, 4	284
KC820745.1	-	3, 4	284
KC820746.1	-	3, 4	284
KC820747.1	-	3, 4	284
KC820748.1	-	3, 4	284
KC820749.1	-	3, 4	284
KC820750.1	-	3, 4	284
KC820751.1	-	3, 4	284
KC820752.1	-	3, 4	284
KC820753.1	-	3, 4	284
KC820754.1	-	3, 4	284
KC820755.1	-	3, 4	284
KC820756.1	-	3, 4	284
KC820757.1	-	3, 4	284
KC820758.1	-	3, 4	284
KC820759.1	-	2, 3	173
KC820760.1	-	3, 4	284
KC820761.1	-	3, 4	284
KC820762.1	-	3, 4	284
KC820763.1	-	3, 4	284
KC820764.1	-	3, 4	284
KC820765.1	-	3, 4	284
KC820766.1	-	3, 4	284
KC820767.1	-	3, 4	284
KC820768.1	-	3, 4	284
KC820769.1	-	3, 4	284
KC820770.1	-	3, 4	284
KC820771.1	-	3, 4	284
KC820772.1	-	3, 4	284
KC820773.1	-	3, 4	284
KC820774.1	-	3, 4	284
KC820775.1	-	3, 4	284
KC820776.1	-	3, 4	284
KC820777.1	-	3, 4	284
KC820778.1	-	3, 4	284
KC820779.1	-	3, 4	284
KC820780.1	-	3, 4	284
KC820781.1	-	3, 4	284
KC820782.1	-	3, 4	284
KC820783.1	-	3, 4	284
KC820784.1	-	3, 4	284
KC820785.1	-	3, 4	284
KC820786.1	-	3, 4	284
M14694.1	-	7, 8	914
M14695.1	-	7, 8	910
X01405.1	-	4, 5	490
X02469.1	-	7, 8	924
X60011.1	-	6, 7	789
X60012.1	-	6, 7	789
X60013.1	-	6, 7	789
X60014.1	-	6, 7	789
X60015.1	-	6, 7	789
X60016.1	-	6, 7	789
X60017.1	-	6, 7	789
X60018.1	-	6, 7	789
X60019.1	-	6, 7	789
X60020.1	-	6, 7	789

More Information

Other Species Targeted

This siRNA also targets the following transcripts in Rat: XM_003749209.

Panther Classification:

Molecular Function -

P53-like transcription factor

Gene Ontology Categories:

Process(es)

negative regulation of transcription from RNA polymerase II promoter
DNA strand renaturation
base-excision repair
nucleotide-excision repair
regulation of transcription, DNA-templated
transcription from RNA polymerase II promoter
protein complex assembly
cellular response to DNA damage stimulus
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
ER overload response
cell cycle arrest
Ras protein signal transduction
multicellular organism development
cell aging
protein localization
cell proliferation
negative regulation of cell proliferation
determination of adult lifespan
response to X-ray
response to gamma radiation
positive regulation of gene expression
viral process
protein sumoylation
cell differentiation
negative regulation of cell growth
DNA damage response, signal transduction by p53 class mediator
positive regulation of histone deacetylation
chromatin assembly
mitotic G1 DNA damage checkpoint
positive regulation of protein oligomerization
cellular response to UV
cellular response to drug
cellular response to glucose starvation
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
regulation of apoptotic process
positive regulation of apoptotic process
negative regulation of apoptotic process
entrainment of circadian clock by photoperiod
proteasome-mediated ubiquitin-dependent protein catabolic process
positive regulation of neuron apoptotic process
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
response to antibiotic
positive regulation of protein export from nucleus
regulation of mitochondrial membrane permeability
negative regulation of fibroblast proliferation
circadian behavior
positive regulation of peptidyl-tyrosine phosphorylation
negative regulation of helicase activity
protein tetramerization
negative regulation of telomerase activity
positive regulation of thymocyte apoptotic process
positive regulation of cell cycle arrest
cellular response to hypoxia
cellular response to ionizing radiation
intrinsic apoptotic signaling pathway by p53 class mediator
positive regulation of release of cytochrome c from mitochondria
replicative senescence
oxidative stress-induced premature senescence
intrinsic apoptotic signaling pathway
oligodendrocyte apoptotic process
positive regulation of execution phase of apoptosis
positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
regulation of signal transduction by p53 class mediator
regulation of cell cycle G2/M phase transition
positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
positive regulation of reactive oxygen species metabolic process
positive regulation of intrinsic apoptotic signaling pathway

Function(s)

RNA polymerase II transcription factor activity, sequence-specific DNA binding
core promoter sequence-specific DNA binding
RNA polymerase II transcription factor binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
protease binding
p53 binding
DNA binding
chromatin binding
damaged DNA binding
double-stranded DNA binding
transcription factor activity, sequence-specific DNA binding
copper ion binding
protein binding
ATP binding
transcription factor binding
zinc ion binding
enzyme binding
protein kinase binding
protein phosphatase binding
receptor tyrosine kinase binding
ubiquitin protein ligase binding
histone acetyltransferase binding
identical protein binding
sequence-specific DNA binding
protein self-association
transcription regulatory region DNA binding
protein heterodimerization activity
protein N-terminus binding
chaperone binding
protein phosphatase 2A binding