n292395

• Gene Symbol: ERCC2
• Gene Name: ERCC excision repair 2, TFIIH core complex helicase subunit
• Gene Aliases: COFS2, EM9, TFIIH, TTD, TTD1, XPD
• Chromosome Location: Chr.19: 45349837 - 45370647 on Build GRCh38
• UniGene ID: Hs.487294
• Species: Human
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: ERCC2
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	XM_011526611.2	XP_011524913.1	22	2983
	XM_017026467.1	XP_016881956.1	22	2897

Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID	Transcript Location
GenBankmRNA	HY042126.1	-	1	401		Chr. 19 - 45350913 - 45351358 [-] on Build GRCh38
GenBankmRNA	BM743465.1	-	1	438		Chr. 19 - 45350893 - 45351395 [-] on Build GRCh38
GenBankmRNA	CR741662.1	-	1	346		Chr. 19 - 45350808 - 45351303 [-] on Build GRCh38
GenBankmRNA	BM743074.1	-	1	438		Chr. 19 - 45350720 - 45351395 [-] on Build GRCh38
GenBankmRNA	CR613691.1	-	1	357		Chr. 19 - 45349870 - 45351314 [-] on Build GRCh38
GenBankmRNA	BX343070.2	-	1	357		Chr. 19 - 45350393 - 45351314 [-] on Build GRCh38
GenBankmRNA	BQ440979.1	-		215		Chr. - - [-] on Build
GenBankmRNA	BM746980.1	-	1	438		Chr. 19 - 45350880 - 45351395 [-] on Build GRCh38

More Information

Panther Classification:

Molecular Function -

DNA helicase

Gene Ontology Categories:

Process(es)

nucleotide-excision repair, DNA duplex unwinding
response to hypoxia
in utero embryonic development
transcription-coupled nucleotide-excision repair
nucleotide-excision repair
nucleotide-excision repair, preincision complex stabilization
nucleotide-excision repair, preincision complex assembly
nucleotide-excision repair, DNA incision, 3'-to lesion
nucleotide-excision repair, DNA incision, 5'-to lesion
transcription initiation from RNA polymerase I promoter
transcription elongation from RNA polymerase I promoter
termination of RNA polymerase I transcription
transcription from RNA polymerase II promoter
transcription initiation from RNA polymerase II promoter
transcription elongation from RNA polymerase II promoter
7-methylguanosine mRNA capping
protein phosphorylation
apoptotic process
response to oxidative stress
chromosome segregation
aging
cell proliferation
UV protection
post-embryonic development
viral process
spinal cord development
extracellular matrix organization
bone mineralization
central nervous system myelin formation
nucleotide-excision repair, DNA incision
multicellular organism growth
hair cell differentiation
embryonic cleavage
erythrocyte maturation
positive regulation of DNA binding
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
hair follicle maturation
hematopoietic stem cell differentiation
global genome nucleotide-excision repair
regulation of mitotic cell cycle phase transition

Function(s)

DNA binding
ATP-dependent DNA helicase activity
protein kinase activity
protein binding
ATP binding
protein C-terminus binding
DNA-dependent ATPase activity
RNA polymerase II carboxy-terminal domain kinase activity
5'-3' DNA helicase activity
metal ion binding
protein N-terminus binding
4 iron, 4 sulfur cluster binding