s10919 Validated

• Gene Symbol: PPM1A
• Gene Name: protein phosphatase, Mg2+/Mn2+ dependent 1A
• Gene Aliases: PP2C-ALPHA, PP2CA, PP2Calpha
• Chromosome Location: Chr.14: 60245752 - 60299087 on Build GRCh38
• UniGene ID: Hs.130036
• Species: Human
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: PPM1A
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_021003.4	NP_066283.1	2	1228
	NM_177951.2	NP_808820.1	3	1330
	NM_177952.2	NP_808821.2	2	1093
	XM_005267779.1	XP_005267836.1	3	1175
	XM_005267781.1	XP_005267838.1	3	1333
	XM_011536872.1	XP_011535174.1	5	1595
	XM_011536876.1	XP_011535178.1	4	1452
	XM_011536877.1	XP_011535179.1	5	1495
	XM_011536878.1	XP_011535180.1	4	1418
	XM_011536879.2	XP_011535181.1	4	1287
	XM_011536880.2	XP_011535182.1	5	1341
	XM_011536881.2	XP_011535183.1	3	1201
	XM_011536882.2	XP_011535184.1	2	870
	XM_011536883.1	XP_011535185.1	3	1284
	XM_011536884.1	XP_011535186.1	2	841
	XM_017021381.1	XP_016876870.1	5	2465
	XM_017021382.1	XP_016876871.1	7	1715
	XM_017021383.1	XP_016876872.1	4	1351
	XM_017021384.1	XP_016876873.1	4	1043
	XM_017021385.1	XP_016876874.1	3	1318
	XM_017021386.1	XP_016876875.1	3	1081
	XM_017021387.1	XP_016876876.1	4	1327
GenBank mRNA	AB451247.1	-	1	778
	AB451371.1	-	1	778
	AF070670.1	-	3	1137
	AK097843.1	-	2	1093
	AK308225.1	-	2	955
	AK313337.1	-	3	1175
	BC026691.1	-	2	1081	3847638
	BC063243.1	-	2	1011	6011486
	S87759.1	-	2	1135

More Information

Other Species Targeted

This siRNA also targets the following transcripts in Rat: NM_017038, XM_006240195, XM_006240194, XM_006240193, J04503.
This siRNA also targets the following transcripts in Mouse: NM_008910, BC008595, AF369981, AF259673, AK210783, and others.

Matching Taqman Gene Expression Assay:

Hs00221372_m1

Gene Ontology Categories:

Process(es)

negative regulation of transcription from RNA polymerase II promoter
protein dephosphorylation
N-terminal protein myristoylation
cell cycle arrest
negative regulation of SMAD protein complex assembly
Wnt signaling pathway
dephosphorylation
positive regulation of Wnt signaling pathway
negative regulation of transforming growth factor beta receptor signaling pathway
negative regulation of BMP signaling pathway
peptidyl-threonine dephosphorylation
negative regulation of NF-kappaB import into nucleus
positive regulation of I-kappaB kinase/NF-kappaB signaling
negative regulation of I-kappaB kinase/NF-kappaB signaling
positive regulation of transcription, DNA-templated
positive regulation of protein export from nucleus
cellular response to transforming growth factor beta stimulus

Function(s)

magnesium ion binding
protein serine/threonine phosphatase activity
signal transducer activity
protein binding
manganese ion binding
calmodulin-dependent protein phosphatase activity
R-SMAD binding