s11750 Validated

• Gene Symbol: RAF1
• Gene Name: Raf-1 proto-oncogene, serine/threonine kinase
• Gene Aliases: CMD1NN, CRAF, NS5, Raf-1, c-Raf
• Chromosome Location: Chr.3: 12583601 - 12664201 on Build GRCh38
• UniGene ID: Hs.159130
• Species: Human
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: RAF1
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_002880.3	NP_002871.1	5	907
	XM_005265355.2	XP_005265412.1	5	635
	XM_005265357.2	XP_005265414.1	5	823
	XM_005265358.4	XP_005265415.1	4	789
	XM_005265359.4	XP_005265416.1	4	789
	XM_011533974.2	XP_011532276.1	6	950
	XM_011533975.2	XP_011532277.1	5	839
	XM_017006966.1	XP_016862455.1	5	611
GenBank mRNA	AK226028.1	-	5	823
	AK303561.1	-	4	710
	AK303920.1	-	1	83
	AK312248.1	-	5	801
	BC018119.2	-	5	821	3904404
	KU178297.1	-	4	492
	KU178298.1	-	4	492
	KU178299.1	-	4	492
	X03484.1	-	5	621

More Information

Other Species Targeted

This siRNA also targets the following transcripts in Rat: NM_012639, XM_008763217, XM_008763218, M15427, BC062071.
This siRNA also targets the following transcripts in Mouse: NM_029780, AK199760, AK036317, BC015273, AK141745, and others.

Matching Taqman Gene Expression Assay:

Hs00234119_m1

Panther Classification:

Molecular Function -

non-receptor serine/threonine protein kinase

Gene Ontology Categories:

Process(es)

MAPK cascade
activation of MAPKK activity
response to hypoxia
stimulatory C-type lectin receptor signaling pathway
protein phosphorylation
apoptotic process
signal transduction
activation of adenylate cyclase activity
heart development
cell proliferation
negative regulation of cell proliferation
cell differentiation
platelet activation
thyroid gland development
negative regulation of protein complex assembly
positive regulation of peptidyl-serine phosphorylation
ion transmembrane transport
somatic stem cell population maintenance
regulation of Rho protein signal transduction
insulin secretion involved in cellular response to glucose stimulus
response to muscle stretch
wound healing
regulation of apoptotic process
negative regulation of apoptotic process
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
intermediate filament cytoskeleton organization
regulation of cell differentiation
positive regulation of transcription from RNA polymerase II promoter
neurotrophin TRK receptor signaling pathway
thymus development
face development
death-inducing signaling complex assembly
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
regulation of cell motility

Function(s)

protein kinase activity
protein serine/threonine kinase activity
MAP kinase kinase kinase activity
protein binding
ATP binding
kinase activity
small GTPase binding
mitogen-activated protein kinase kinase binding
identical protein binding
metal ion binding
protein heterodimerization activity