s128173

• Gene Symbol: Pdgfb
• Gene Name: platelet-derived growth factor beta polypeptide
• Gene Aliases: SIS, c-sis
• Chromosome Location: Chr.7: 121215458 - 121233092 on Build Rnor_6.0
• UniGene ID: Rn.198230
• Species: Rat
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: Pdgfb
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_031524.1	NP_113712.1	2, 3	552
GenBank mRNA	CB580369.1	-	2, 3	562
	Z14117.1	-	2, 3	133

More Information

Panther Classification:

Molecular Function -

growth factor

Gene Ontology Categories:

Process(es)

response to hypoxia
embryonic placenta development
positive regulation of endothelial cell proliferation
monocyte chemotaxis
positive regulation of glomerular filtration
DNA replication
protein phosphorylation
substrate-dependent cell migration
heart development
blood coagulation
positive regulation of cell proliferation
response to wounding
response to organic substance
negative regulation of phosphatidylinositol biosynthetic process
negative regulation of platelet activation
positive regulation of phosphatidylinositol 3-kinase signaling
response to organic cyclic compound
positive regulation of smooth muscle cell migration
cell growth
peptidyl-serine phosphorylation
peptidyl-tyrosine phosphorylation
cell projection assembly
actin cytoskeleton organization
hemopoiesis
positive regulation of cell migration
negative regulation of cell migration
positive regulation of protein autophosphorylation
activation of protein kinase activity
activation of protein kinase B activity
response to estradiol
response to insulin
positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway
paracrine signaling
wound healing
regulation of cell proliferation
response to drug
positive regulation of MAP kinase activity
positive regulation of MAPK cascade
positive regulation of blood vessel endothelial cell migration
positive regulation of phosphatidylinositol 3-kinase activity
response to estrogen
positive regulation of cyclin-dependent protein serine/threonine kinase activity
positive regulation of DNA replication
positive regulation of fibroblast growth factor receptor signaling pathway
positive regulation of mitotic nuclear division
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of mitotic cell cycle, embryonic
platelet-derived growth factor receptor signaling pathway
positive regulation of fibroblast proliferation
blood vessel morphogenesis
positive regulation of smooth muscle cell proliferation
regulation of peptidyl-tyrosine phosphorylation
positive regulation of peptidyl-tyrosine phosphorylation
positive chemotaxis
positive regulation of chemotaxis
cell chemotaxis
branching involved in salivary gland morphogenesis
epithelial cell proliferation involved in salivary gland morphogenesis
positive regulation of protein tyrosine kinase activity
positive regulation of ERK1 and ERK2 cascade
cellular response to growth factor stimulus
cellular response to mycophenolic acid
positive regulation of glomerular mesangial cell proliferation
metanephric glomerular mesangial cell development
metanephric glomerular mesangial cell proliferation involved in metanephros development
metanephric glomerular endothelium development
reactive oxygen species metabolic process
positive regulation of calcium ion import
positive regulation of hyaluronan biosynthetic process
positive regulation of reactive oxygen species metabolic process
positive regulation of DNA biosynthetic process
positive regulation of metanephric mesenchymal cell migration

Function(s)

receptor binding
platelet-derived growth factor receptor binding
collagen binding
growth factor activity
superoxide-generating NADPH oxidase activator activity
chemoattractant activity
identical protein binding
protein homodimerization activity
protein heterodimerization activity
platelet-derived growth factor binding