s12818

• Gene Symbol: SHH
• Gene Name: sonic hedgehog
• Gene Aliases: HHG1, HLP3, HPE3, MCOPCB5, SMMCI, TPT, TPTPS
• Chromosome Location: Chr.7: 155799984 - 155812273 on Build GRCh38
• UniGene ID: Hs.164537
• Species: Human
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: SHH
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_000193.3	NP_000184.1	1	405
GenBank mRNA	BX452210.1	-	1	310
	L38518.1	-	1	405

More Information

Other Species Targeted

This siRNA also targets the following transcripts in Rat: NM_017221, L27340.
This siRNA also targets the following transcripts in Mouse: NM_009170, AK077688, EU664592, X76290, BC063087.

Gene Ontology Categories:

Process(es)

negative regulation of transcription from RNA polymerase II promoter
patterning of blood vessels
vasculogenesis
metanephros development
branching involved in ureteric bud morphogenesis
cell fate specification
neural crest cell migration
heart looping
positive regulation of neuroblast proliferation
osteoblast development
lymphoid progenitor cell differentiation
determination of left/right asymmetry in lateral mesoderm
endocytosis
smoothened signaling pathway
positive regulation of hh target transcription factor activity
cell-cell signaling
pattern specification process
ectoderm development
neuroblast proliferation
axon guidance
central nervous system development
ventral midline development
hindgut morphogenesis
heart development
blood coagulation
androgen metabolic process
positive regulation of cell proliferation
embryo development
embryonic pattern specification
polarity specification of anterior/posterior axis
dorsal/ventral pattern formation
oligodendrocyte development
striated muscle tissue development
positive regulation of skeletal muscle cell proliferation
myotube differentiation
intein-mediated protein splicing
spinal cord dorsal/ventral patterning
spinal cord motor neuron differentiation
thalamus development
dorsal/ventral neural tube patterning
cerebellar granule cell precursor proliferation
smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation
telencephalon regionalization
establishment of cell polarity
regulation of proteolysis
positive regulation of Wnt signaling pathway
lung development
embryonic limb morphogenesis
negative regulation of cell migration
male genitalia development
prostate gland development
thyroid gland development
forebrain development
midbrain development
hindbrain development
pancreas development
hair follicle morphogenesis
negative regulation of proteasomal ubiquitin-dependent protein catabolic process
T cell differentiation in thymus
positive regulation of T cell differentiation in thymus
positive regulation of immature T cell proliferation in thymus
negative regulation of transcription elongation from RNA polymerase II promoter
protein localization to nucleus
embryonic forelimb morphogenesis
embryonic hindlimb morphogenesis
regulation of cell proliferation
negative regulation of T cell proliferation
positive regulation of protein import into nucleus
odontogenesis of dentin-containing tooth
regulation of odontogenesis
embryonic digit morphogenesis
camera-type eye development
negative regulation of apoptotic process
CD4-positive or CD8-positive, alpha-beta T cell lineage commitment
positive thymic T cell selection
negative thymic T cell selection
intermediate filament organization
myoblast differentiation
negative regulation of cell differentiation
positive regulation of smoothened signaling pathway
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
positive regulation of alpha-beta T cell differentiation
negative regulation of alpha-beta T cell differentiation
cell development
thymus development
embryonic digestive tract morphogenesis
embryonic foregut morphogenesis
positive regulation of skeletal muscle tissue development
organ formation
neuron fate commitment
embryonic skeletal system development
positive regulation of oligodendrocyte differentiation
branching morphogenesis of an epithelial tube
inner ear development
formation of anatomical boundary
stem cell development
positive regulation of striated muscle cell differentiation
positive regulation of cell division
Bergmann glial cell differentiation
palate development
canonical Wnt signaling pathway
limb bud formation
lung epithelium development
trachea morphogenesis
branching involved in salivary gland morphogenesis
bud outgrowth involved in lung branching
right lung development
left lung development
lung lobe morphogenesis
lung-associated mesenchyme development
primary prostatic bud elongation
prostate epithelial cord elongation
salivary gland cavitation
epithelial cell proliferation involved in salivary gland morphogenesis
regulation of prostatic bud formation
epithelial-mesenchymal signaling involved in prostate gland development
positive regulation of epithelial cell proliferation involved in prostate gland development
regulation of mesenchymal cell proliferation involved in prostate gland development
mesenchymal smoothened signaling pathway involved in prostate gland development
artery development
mesenchymal cell proliferation involved in lung development
somite development
positive regulation of sclerotome development
cellular response to lithium ion
dopaminergic neuron differentiation
renal system development
metanephric mesenchymal cell proliferation involved in metanephros development
multicellular structure septum development
negative regulation of canonical Wnt signaling pathway
negative regulation of cholesterol efflux
apoptotic signaling pathway
regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry
regulation of protein localization to nucleus
negative regulation of dopaminergic neuron differentiation
negative regulation of ureter smooth muscle cell differentiation
positive regulation of ureter smooth muscle cell differentiation
negative regulation of kidney smooth muscle cell differentiation
positive regulation of kidney smooth muscle cell differentiation
positive regulation of mesenchymal cell proliferation involved in ureter development
negative regulation of mesenchymal cell apoptotic process

Function(s)

glycoprotein binding
patched binding
calcium ion binding
protein binding
glycosaminoglycan binding
peptidase activity
zinc ion binding
morphogen activity
laminin-1 binding