s13766 Validated

• Gene Symbol: MAP3K7
• Gene Name: mitogen-activated protein kinase kinase kinase 7
• Gene Aliases: MEKK7, TAK1, TGF1a
• Chromosome Location: Chr.6: 90513573 - 90587301 on Build GRCh38
• UniGene ID: Hs.594838
• Species: Human
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: MAP3K7
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_003188.3	NP_003179.1	3	673
	NM_145331.2	NP_663304.1	3	673
	NM_145332.2	NP_663305.1	3	673
	NM_145333.2	NP_663306.1	3	673
	XM_006715553.2	XP_006715616.1	3	441
	XM_017011226.1	XP_016866715.1	3	441
GenBank mRNA	AB009356.1	-	3	417
	AB009357.1	-	3	417
	AB009358.2	-	3	255
	AF218074.1	-	3	261
	AK315774.1	-	3	441
	AL520975.3	-	3	567
	BC017715.2	-	3	440	3906837
	BM172351.1	-	3	681
	BT019654.1	-	3	255
	BT019655.1	-	3	255

More Information

Other Species Targeted

This siRNA also targets the following transcripts in Rat: NM_001107920, XM_003750753, XM_006237966, XM_006245614.

Matching Taqman Gene Expression Assay:

Hs00177373_m1

Panther Classification:

Molecular Function -

non-receptor serine/threonine protein kinase, protein modifying enzyme

Gene Ontology Categories:

Process(es)

activation of MAPKK activity
activation of MAPK activity
stimulatory C-type lectin receptor signaling pathway
positive regulation of T cell cytokine production
MyD88-dependent toll-like receptor signaling pathway
transcription, DNA-templated
apoptotic process
transforming growth factor beta receptor signaling pathway
Wnt signaling pathway, calcium modulating pathway
I-kappaB kinase/NF-kappaB signaling
activation of NF-kappaB-inducing kinase activity
I-kappaB phosphorylation
JNK cascade
positive regulation of interleukin-2 production
Fc-epsilon receptor signaling pathway
positive regulation of I-kappaB kinase/NF-kappaB signaling
positive regulation of JUN kinase activity
histone H3 acetylation
T cell receptor signaling pathway
positive regulation of T cell activation
positive regulation of NF-kappaB transcription factor activity
stress-activated MAPK cascade
nucleotide-binding oligomerization domain containing signaling pathway

Function(s)

magnesium ion binding
protein kinase activity
protein serine/threonine kinase activity
MAP kinase kinase kinase activity
protein binding
ATP binding
scaffold protein binding