s14116 Validated

• Gene Symbol: THRA
• Gene Name: thyroid hormone receptor, alpha
• Gene Aliases: AR7, CHNG6, EAR7, ERB-T-1, ERBA, ERBA1, NR1A1, THRA1, THRA2, c-ERBA-1
• Chromosome Location: Chr.17: 40062193 - 40093867 on Build GRCh38
• UniGene ID: Hs.724
• Species: Human
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: THRA
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_001190918.1	NP_001177847.1	4	714
	NM_001190919.1	NP_001177848.1	4	695
	NM_003250.5	NP_003241.2	4	714
	NM_199334.3	NP_955366.1	4	714
GenBank mRNA	AB209346.1	-	4	720
	AB307686.1	-	3	139
	AK290071.1	-	4	541
	AK290530.1	-	4	695
	AK311344.1	-	4	489
	BC000261.1	-	4	563	3501886
	BC002728.2	-	4	563	3628335
	BC008851.2	-	4	785	4137980
	BC035137.1	-	4	723	5264048
	CR541915.1	-	3	139
	HQ692859.1	-	3	139
	J03239.1	-	3	196
	M24899.1	-	4	550
	X55005.1	-	4	605
	Y00479.1	-	4	472

More Information

Other Species Targeted

This siRNA also targets the following transcripts in Rat: NM_001017960, NM_031134, X07409, CB580585, M18028, and others.
This siRNA also targets the following transcripts in Mouse: NM_178060, BC046795, AK082121, X51983, X07751, and others.

Matching Taqman Gene Expression Assay:

Hs00268470_m1

Panther Classification:

Molecular Function -

C4 zinc finger nuclear receptor, DNA-binding transcription factor, zinc finger transcription factor, gene-specific transcriptional regulator

Gene Ontology Categories:

Process(es)

cartilage condensation
ossification
kidney development
liver development
regulation of thyroid hormone mediated signaling pathway
regulation of transcription from RNA polymerase II promoter
transcription from RNA polymerase II promoter
transcription initiation from RNA polymerase II promoter
brain development
learning or memory
regulation of heart contraction
female courtship behavior
response to cold
hormone-mediated signaling pathway
positive regulation of myotube differentiation
negative regulation of RNA polymerase II transcriptional preinitiation complex assembly
erythrocyte differentiation
adrenal gland development
intracellular receptor signaling pathway
thyroid gland development
response to nutrient levels
regulation of myeloid cell apoptotic process
response to drug
cytoplasmic sequestering of transcription factor
steroid hormone mediated signaling pathway
negative regulation of sequence-specific DNA binding transcription factor activity
negative regulation of transcription, DNA-templated
positive regulation of female receptivity
positive regulation of transcription from RNA polymerase II promoter
digestive tract development
embryonic organ development
regulation of lipid catabolic process
Type I pneumocyte differentiation
negative regulation of DNA-templated transcription, initiation

Function(s)

transcription regulatory region sequence-specific DNA binding
steroid receptor RNA activator RNA binding
transcription factor activity, sequence-specific DNA binding
transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
steroid hormone receptor activity
thyroid hormone receptor activity
protein binding
transcription factor binding
zinc ion binding
TBP-class protein binding
protein domain specific binding
chromatin DNA binding
protein complex binding
protein homodimerization activity
transcription regulatory region DNA binding
intronic transcription regulatory region DNA binding
protein heterodimerization activity
thyroid hormone binding