s14389 Validated

• Gene Symbol: TRAF6
• Gene Name: TNF receptor associated factor 6
• Gene Aliases: MGC:3310, RNF85
• Chromosome Location: Chr.11: 36483767 - 36510313 on Build GRCh38
• UniGene ID: Hs.444172
• Species: Human
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: TRAF6
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_004620.3	NP_004611.1	5, 6	977
	NM_145803.2	NP_665802.1	6, 7	1070
GenBank mRNA	AK292978.1	-	5, 6	936
	BC031052.1	-	6, 7	1015	5272008
	U78798.1	-	5, 6	910

More Information

Other Species Targeted

This siRNA also targets the following transcripts in Rat: NM_001107754, BC168921.

Matching Taqman Gene Expression Assay:

Hs00371508_m1

Panther Classification:

Molecular Function -

scaffold/adaptor protein

Gene Ontology Categories:

Process(es)

negative regulation of transcription from RNA polymerase II promoter
activation of MAPK activity
protein polyubiquitination
ossification
neural tube closure
stimulatory C-type lectin receptor signaling pathway
toll-like receptor signaling pathway
positive regulation of T cell cytokine production
MyD88-dependent toll-like receptor signaling pathway
MyD88-independent toll-like receptor signaling pathway
protein complex assembly
I-kappaB kinase/NF-kappaB signaling
activation of NF-kappaB-inducing kinase activity
JNK cascade
antigen processing and presentation of exogenous peptide antigen via MHC class II
osteoclast differentiation
membrane protein intracellular domain proteolysis
positive regulation of protein ubiquitination
positive regulation of lipopolysaccharide-mediated signaling pathway
activation of protein kinase activity
positive regulation of interleukin-2 production
toll-like receptor 9 signaling pathway
Fc-epsilon receptor signaling pathway
T-helper 1 type immune response
positive regulation of T cell proliferation
odontogenesis of dentin-containing tooth
myeloid dendritic cell differentiation
positive regulation of apoptotic process
negative regulation of apoptotic process
positive regulation of I-kappaB kinase/NF-kappaB signaling
positive regulation of JUN kinase activity
positive regulation of interleukin-12 biosynthetic process
positive regulation of interleukin-6 biosynthetic process
bone resorption
positive regulation of osteoclast differentiation
negative regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
cell development
positive regulation of smooth muscle cell proliferation
T cell receptor signaling pathway
positive regulation of T cell activation
regulation of immunoglobulin secretion
positive regulation of sequence-specific DNA binding transcription factor activity
positive regulation of NF-kappaB transcription factor activity
protein autoubiquitination
nucleotide-binding oligomerization domain containing signaling pathway
interleukin-1-mediated signaling pathway
protein K63-linked ubiquitination
response to interleukin-1
cellular response to lipopolysaccharide
positive regulation of transcription regulatory region DNA binding

Function(s)

ubiquitin-protein transferase activity
tumor necrosis factor receptor binding
protein binding
zinc ion binding
ligase activity
protein kinase binding
mitogen-activated protein kinase kinase kinase binding
ubiquitin conjugating enzyme binding
ubiquitin protein ligase binding
thioesterase binding
identical protein binding
histone deacetylase binding
protein kinase B binding
protein N-terminus binding
ubiquitin protein ligase activity