s1702

• Gene Symbol: ATF4
• Gene Name: activating transcription factor 4
• Gene Aliases: CREB-2, CREB2, TAXREB67, TXREB
• Chromosome Location: Chr.22: 39519709 - 39522686 on Build GRCh38
• UniGene ID: Hs.496487
• Species: Human
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: ATF4
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_001675.4	NP_001666.2	1	984
	NM_182810.2	NP_877962.1	2	377
	XM_017028807.1	XP_016884296.1	3	856
GenBank mRNA	AK057751.1	-	2	381
	AK296028.1	-	2	383
	BC008090.1	-	2	361	3454473
	BC011994.1	-	2	359	3882614
	BC016855.2	-	2	353	3850361
	BC022088.2	-	2	360	3030097
	BC024775.1	-	2	359	4992862
	BC044895.1	-	2	345	4513828
	BC073754.1	-	2	350	6580199
	BC073990.1	-	2	325	6022488
	CR450353.1	-	1	97
	CR456384.1	-	1	277
	D90209.1	-	1	978
	M86842.1	-	1	204

More Information

Other Species Targeted

This siRNA also targets the following transcripts in Rat: NM_024403, FQ210065, FQ214151, FQ221881, FQ215912, and others.
This siRNA also targets the following transcripts in Mouse: NM_009716, NM_001287180, AK144777, AK003001, AK156298, and others.

Panther Classification:

Molecular Function -

DNA-binding transcription factor

Gene Ontology Categories:

Process(es)

gluconeogenesis
regulation of transcription, DNA-templated
transcription from RNA polymerase II promoter
cellular amino acid metabolic process
gamma-aminobutyric acid signaling pathway
positive regulation of vascular endothelial growth factor production
positive regulation of gene expression
negative regulation of translational initiation in response to stress
circadian regulation of gene expression
cellular response to amino acid starvation
cellular response to UV
response to endoplasmic reticulum stress
positive regulation of transcription from RNA polymerase II promoter in response to stress
positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress
PERK-mediated unfolded protein response
cellular response to glucose starvation
mRNA transcription from RNA polymerase II promoter
positive regulation of apoptotic process
negative regulation of potassium ion transport
positive regulation of neuron apoptotic process
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase I promoter
positive regulation of transcription from RNA polymerase II promoter
positive regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
negative regulation of oxidative stress-induced neuron death
positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
response to manganese-induced endoplasmic reticulum stress

Function(s)

RNA polymerase II regulatory region sequence-specific DNA binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
core promoter sequence-specific DNA binding
transcription factor activity, RNA polymerase II transcription factor binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
RNA polymerase II transcription factor binding
DNA binding
transcription factor activity, sequence-specific DNA binding
protein binding
protein C-terminus binding
leucine zipper domain binding
sequence-specific DNA binding
transcription regulatory region DNA binding
protein heterodimerization activity