s194692

• Gene Symbol: PML
• Gene Name: promyelocytic leukemia
• Gene Aliases: MYL, PP8675, RNF71, TRIM19
• Chromosome Location: Chr.15: 73994673 - 74047819 on Build GRCh38
• UniGene ID: Hs.526464
• Species: Human
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: PML
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_002675.3	NP_002666.1	2	507
	NM_033238.2	NP_150241.2	2	507
	NM_033239.2	NP_150242.1	2	507
	NM_033240.2	NP_150243.2	2	507
	NM_033244.3	NP_150247.2	2	507
	NM_033246.2	NP_150249.1	2	507
	NM_033247.2	NP_150250.2	2	507
	NM_033249.2	NP_150252.1	2	507
	NM_033250.2	NP_150253.2	2	507
GenBank mRNA	AB208950.1	-	2	377
	AB209051.1	-	1	218
	AB209411.1	-	2	451
	AF230401.1	-	2	439
	AF230402.1	-	2	439
	AF230403.1	-	2	439
	AF230404.1	-	2	439
	AF230405.1	-	2	439
	AF230406.1	-	2	439
	AF230407.1	-	2	439
	AF230408.1	-	2	439
	AF230409.1	-	2	439
	AF230410.1	-	2	439
	AF230411.1	-	2	439
	AK300951.1	-	2	389
	BC000080.2	-	2	428	3506984
	BC020994.2	-	2	428	2958462
	BT009911.1	-	2	367
	M73778.1	-	2	447
	M79462.1	-	2	381
	M79463.1	-	2	381
	M79464.1	-	2	381
	M80185.1	-	2	381
	S50913.1	-	2	449
	X63131.1	-	2	508

More Information

Other Species Targeted

This siRNA also targets the following transcripts in Rat: XM_008766431.

Gene Ontology Categories:

Process(es)

response to hypoxia
regulation of protein phosphorylation
transcription, DNA-templated
regulation of transcription, DNA-templated
protein complex assembly
activation of cysteine-type endopeptidase activity involved in apoptotic process
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
cell cycle arrest
transforming growth factor beta receptor signaling pathway
common-partner SMAD protein phosphorylation
SMAD protein import into nucleus
negative regulation of cell proliferation
intrinsic apoptotic signaling pathway in response to oxidative stress
response to UV
response to gamma radiation
regulation of calcium ion transport into cytosol
fibroblast migration
negative regulation of angiogenesis
protein sumoylation
myeloid cell differentiation
regulation of cell adhesion
negative regulation of cell growth
PML body organization
positive regulation of telomere maintenance
endoplasmic reticulum calcium ion homeostasis
circadian regulation of gene expression
response to cytokine
regulation of circadian rhythm
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
entrainment of circadian clock by photoperiod
proteasome-mediated ubiquitin-dependent protein catabolic process
innate immune response
cell fate commitment
regulation of MHC class I biosynthetic process
negative regulation of transcription, DNA-templated
positive regulation of fibroblast proliferation
retinoic acid receptor signaling pathway
negative regulation of interleukin-1 beta secretion
maintenance of protein location in nucleus
defense response to virus
interferon-gamma-mediated signaling pathway
branching involved in mammary gland duct morphogenesis
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
cellular response to interleukin-4
cellular senescence
extrinsic apoptotic signaling pathway
regulation of signal transduction by p53 class mediator
negative regulation of viral release from host cell
negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
regulation of double-strand break repair
positive regulation of extrinsic apoptotic signaling pathway

Function(s)

DNA binding
protein binding
zinc ion binding
ubiquitin protein ligase binding
SUMO binding
protein homodimerization activity
SMAD binding