s200430 Validated

• Gene Symbol: ERN1
• Gene Name: endoplasmic reticulum to nucleus signaling 1
• Gene Aliases: IRE1, IRE1P, IRE1a, hIRE1p
• Chromosome Location: Chr.17: 64039142 - 64130819 on Build GRCh38
• UniGene ID: Hs.133982
• Species: Human
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: ERN1
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_001433.3	NP_001424.3	4, 5	403
	XM_017024347.1	XP_016879836.1	4, 5	1757
	XM_017024348.1	XP_016879837.1	4, 5	1757
GenBank mRNA	AB209869.1	-	4, 5	386
	AF059198.1	-	4, 5	386
	AK292403.1	-	4, 5	429
	BC130405.1	-	4, 5	336	40146436
	BC130407.1	-	4, 5	336	40146438
	DB128514.1	-	4, 5	403

More Information

Matching Taqman Gene Expression Assay:

Hs00176385_m1

Panther Classification:

Molecular Function -

endoribonuclease

Gene Ontology Categories:

Process(es)

endothelial cell proliferation
transcription, DNA-templated
regulation of transcription, DNA-templated
mRNA cleavage
mRNA catabolic process
protein phosphorylation
activation of signaling protein activity involved in unfolded protein response
cell cycle arrest
activation of JUN kinase activity
regulation of macroautophagy
positive regulation of RNA splicing
response to endoplasmic reticulum stress
cellular response to vascular endothelial growth factor stimulus
peptidyl-serine autophosphorylation
IRE1-mediated unfolded protein response
protein autophosphorylation
mRNA splicing, via endonucleolytic cleavage and ligation
mRNA endonucleolytic cleavage involved in unfolded protein response
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
cellular response to glucose stimulus
RNA phosphodiester bond hydrolysis, endonucleolytic
positive regulation of endoplasmic reticulum unfolded protein response
insulin metabolic process
peptidyl-serine trans-autophosphorylation

Function(s)

magnesium ion binding
endoribonuclease activity
protein serine/threonine kinase activity
protein binding
ATP binding
enzyme binding
Hsp70 protein binding
identical protein binding
protein homodimerization activity
ADP binding
Hsp90 protein binding