s220881

• Gene Symbol: Srebf2
• Gene Name: sterol regulatory element binding transcription factor 2
• Gene Aliases: SREBP-2, SREBP2, Srebf2_retired
• Chromosome Location: Chr.7: 123381082 - 123438605 on Build Rnor_6.0
• UniGene ID: Rn.41063
• Species: Rat
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: Srebf2
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_001033694.1	NP_001028866.1	2	623
	XM_006242079.2	XP_006242141.1	2	978
GenBank mRNA	BC101902.1	-	2	623	7934137

More Information

Other Species Targeted

This siRNA also targets the following transcripts in Human: NM_004599, BC051799, AK299914, U02031, CT841522, and others.
This siRNA also targets the following transcripts in Mouse: NM_033218, BC048071, AF374267, AK172219, AK053802, and others.

Gene Ontology Categories:

Process(es)

negative regulation of transcription from RNA polymerase II promoter
transcription, DNA-templated
regulation of transcription, DNA-templated
spermatogenesis
aging
cholesterol metabolic process
lipid biosynthetic process
response to hormone
response to lead ion
positive regulation of cholesterol storage
response to lipid
response to drug
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
response to low-density lipoprotein particle
regulation of lipid transport by negative regulation of transcription from RNA polymerase II promoter
negative regulation of cholesterol efflux
regulation of cholesterol homeostasis

Function(s)

C-8 sterol isomerase activity
RNA polymerase II core promoter proximal region sequence-specific DNA binding
transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
DNA binding
chromatin binding
transcription factor activity, sequence-specific DNA binding
protein C-terminus binding
sequence-specific DNA binding
transcription regulatory region DNA binding
protein dimerization activity
E-box binding