s223927

• Gene Symbol: IKBKB
• Gene Name: inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
• Gene Aliases: IKK-beta, IKK2, IKKB, IMD15, NFKBIKB
• Chromosome Location: Chr.8: 42271302 - 42332653 on Build GRCh38
• UniGene ID: Hs.597664
• Species: Human
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: IKBKB
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_001190720.2	NP_001177649.1	21	2283
	NM_001242778.1	NP_001229707.1	21	2311
	NM_001556.2	NP_001547.1	22	2406
	NR_033818.1		22	2462
	NR_033819.1		21	2344
	NR_040009.1		22	2353
	XM_005273492.3	XP_005273549.1	21	2315
GenBank mRNA	AB209090.1	-	19	3475
	AF029684.1	-	21	2220
	AF031416.1	-	21	2220
	AF080158.1	-	22	2363
	AK091090.1	-	1	572
	AK091297.1	-	16	1802
	AK093537.1	-	1	893
	AK095687.1	-	1	1591
	AK097828.1	-	6	1723
	AK298241.1	-	19	1970
	AK302723.1	-	21	2267
	AK303528.1	-	21	2299
	AK316418.1	-	21	2267
	BC127663.1	-	4	348
	BC141978.1	-	4	348
	BC144080.1	-	21	2197
	BX648165.1	-	20	2796

More Information

Other Species Targeted

This siRNA also targets the following transcripts in Rat: NM_053355, AF115282.
This siRNA also targets the following transcripts in Mouse: NM_001159774, NM_010546, AF088910, AK150884, AK151888, and others.

Panther Classification:

Molecular Function -

non-receptor serine/threonine protein kinase, protein modifying enzyme

Gene Ontology Categories:

Process(es)

stimulatory C-type lectin receptor signaling pathway
skeletal muscle contraction
protein phosphorylation
inflammatory response
I-kappaB kinase/NF-kappaB signaling
I-kappaB phosphorylation
positive regulation of cell proliferation
response to virus
response to toxic substance
regulation of tumor necrosis factor-mediated signaling pathway
positive regulation of neuron projection development
cortical actin cytoskeleton organization
neuron projection development
response to lipopolysaccharide
tumor necrosis factor-mediated signaling pathway
negative regulation of myosin-light-chain-phosphatase activity
TRIF-dependent toll-like receptor signaling pathway
Fc-epsilon receptor signaling pathway
regulation of phosphorylation
response to drug
serine phosphorylation of STAT protein
negative regulation of apoptotic process
positive regulation of I-kappaB kinase/NF-kappaB signaling
innate immune response
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
T cell receptor signaling pathway
positive regulation of NF-kappaB transcription factor activity
stress-activated MAPK cascade
nucleotide-binding oligomerization domain containing signaling pathway
interleukin-1-mediated signaling pathway
response to fatty acid
cellular response to tumor necrosis factor
establishment of protein localization to plasma membrane
positive regulation of neuron death
regulation of establishment of endothelial barrier
negative regulation of bicellular tight junction assembly

Function(s)

protein kinase activity
protein serine/threonine kinase activity
protein binding
ATP binding
IkappaB kinase activity
protein kinase binding
protein homodimerization activity
protein heterodimerization activity
scaffold protein binding