s224356

• Gene Symbol: FBXW7
• Gene Name: F-box and WD repeat domain containing 7
• Gene Aliases: AGO, CDC4, FBW6, FBW7, FBX30, FBXO30, FBXW6, SEL-10, SEL10, hAgo, hCdc4
• Chromosome Location: Chr.4: 152321258 - 152536095 on Build GRCh38
• UniGene ID: Hs.561245
• Species: Human
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: FBXW7
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_001013415.1	NP_001013433.1	8	1098
	NM_018315.4	NP_060785.2	8	1263
	NM_033632.3	NP_361014.1	9	1437
	XM_011532083.1	XP_011530385.1	11	2450
	XM_011532084.1	XP_011530386.1	10	2400
	XM_011532085.1	XP_011530387.1	9	2307
	XM_011532086.1	XP_011530388.1	12	2628
	XM_011532087.1	XP_011530389.1	11	2578
	XM_011532088.1	XP_011530390.1	9	1836
	XM_017008362.1	XP_016863851.1	11	2847
GenBank mRNA	AB209725.1	-	8	1027
	AF383178.1	-	8	837
	AF411971.1	-	8	1350
	AF411972.1	-	8	1131
	AK001933.1	-	8	888
	AK131383.1	-	1	723
	AK223449.1	-	8	1065
	AK294568.1	-	7	824
	AK299722.1	-	7	846
	AK315142.1	-	8	1045
	AY008274.1	-	8	1100
	AY033553.1	-	8	1131
	AY049984.1	-	8	1344
	BC037320.2	-	8	1018
	BC117244.1	-	9	1405	40125795
	BC117246.1	-	9	1405	40125797
	BC143944.1	-	10	1455	9052462
	CR749305.1	-	9	1568

More Information

Gene Ontology Categories:

Process(es)

protein polyubiquitination
vasculature development
sister chromatid cohesion
negative regulation of triglyceride biosynthetic process
regulation of lipid storage
viral process
protein ubiquitination
SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
positive regulation of protein ubiquitination
negative regulation of DNA endoreduplication
regulation of protein localization
positive regulation of epidermal growth factor-activated receptor activity
negative regulation of Notch signaling pathway
protein stabilization
positive regulation of ubiquitin-protein transferase activity
lipid homeostasis
positive regulation of ERK1 and ERK2 cascade
positive regulation of proteasomal protein catabolic process
regulation of cell cycle G1/S phase transition
regulation of mitophagy
positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
positive regulation of protein targeting to mitochondrion
positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
negative regulation of hepatocyte proliferation
negative regulation of SREBP signaling pathway

Function(s)

ubiquitin-protein transferase activity
protein binding
cyclin binding
protein binding, bridging
ubiquitin protein ligase binding
identical protein binding
phosphothreonine binding
ubiquitin-protein transferase activator activity