s224427

• Gene Symbol: PSEN1
• Gene Name: presenilin 1
• Gene Aliases: AD3, FAD, PS-1, PS1, S182
• Chromosome Location: Chr.14: 73136435 - 73223691 on Build GRCh38
• UniGene ID: Hs.3260
• Species: Human
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: PSEN1
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_000021.3	NP_000012.1	11	1458
	NM_007318.2	NP_015557.2	11	1446
	XM_005267864.2	XP_005267921.1	11	1452
	XM_005267866.1	XP_005267923.1	11	1441
	XM_011536971.2	XP_011535273.1	11	1350
	XM_011536972.2	XP_011535274.1	11	1714
	XM_011536973.1	XP_011535275.1	11	1702
	XM_011536974.1	XP_011535276.1	11	1343
GenBank mRNA	AK122722.1	-	9	2727
	AK223173.1	-	9	1188
	AK303876.1	-	7	833
	AK312531.1	-	11	1442
	BC011729.2	-	11	1427	4423098
	KU178285.1	-	9	1162
	KU178286.1	-	9	1174
	KU178287.1	-	4	393
	L42110.1	-	11	1422
	L76517.1	-	11	1715
	U40379.1	-	9	1162
	U40380.1	-	10	1254

More Information

Other Species Targeted

This siRNA also targets the following transcripts in Rat: NM_019163, XM_006240321, XM_006240322, D82363, BC070887, and others.
This siRNA also targets the following transcripts in Mouse: NM_008943, AK165984, BC030409, AK134615, AK148101, and others.

Panther Classification:

Molecular Function -

aspartic protease

Gene Ontology Categories:

Process(es)

autophagosome assembly
negative regulation of transcription from RNA polymerase II promoter
activation of MAPKK activity
blood vessel development
cell fate specification
somitogenesis
neuron migration
positive regulation of receptor recycling
heart looping
hematopoietic progenitor cell differentiation
T cell activation involved in immune response
neural retina development
protein glycosylation
membrane protein ectodomain proteolysis
mitochondrial transport
cellular response to DNA damage stimulus
response to oxidative stress
negative regulation of epidermal growth factor-activated receptor activity
Notch signaling pathway
Notch receptor processing
memory
post-embryonic development
protein transport
L-glutamate transport
choline transport
synaptic vesicle targeting
single organismal cell-cell adhesion
protein processing
cerebral cortex cell migration
Cajal-Retzius cell differentiation
dorsal/ventral neural tube patterning
embryonic limb morphogenesis
positive regulation of proteasomal ubiquitin-dependent protein catabolic process
endoplasmic reticulum calcium ion homeostasis
beta-amyloid formation
intracellular signal transduction
regulation of phosphorylation
amyloid precursor protein catabolic process
myeloid dendritic cell differentiation
positive regulation of apoptotic process
negative regulation of apoptotic process
positive regulation of catalytic activity
regulation of protein binding
positive regulation of MAP kinase activity
negative regulation of neuron apoptotic process
skin morphogenesis
positive regulation of transcription, DNA-templated
regulation of synaptic plasticity
thymus development
neuron development
skeletal system morphogenesis
brain morphogenesis
epithelial cell proliferation
negative regulation of axonogenesis
positive regulation of coagulation
T cell receptor signaling pathway
neuron apoptotic process
negative regulation of ubiquitin-protein transferase activity
smooth endoplasmic reticulum calcium ion homeostasis
regulation of synaptic transmission, glutamatergic
canonical Wnt signaling pathway
regulation of resting membrane potential
positive regulation of dendritic spine development
calcium ion transmembrane transport
negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
negative regulation of apoptotic signaling pathway

Function(s)

endopeptidase activity
aspartic-type endopeptidase activity
calcium channel activity
protein binding
beta-catenin binding
PDZ domain binding
cadherin binding