s225196

• Gene Symbol: NR1H4
• Gene Name: nuclear receptor subfamily 1 group H member 4
• Gene Aliases: BAR, FXR, HRR-1, HRR1, RIP14
• Chromosome Location: Chr.12: 100473773 - 100563867 on Build GRCh38
• UniGene ID: Hs.282735
• Species: Human
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: NR1H4
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_001206992.1	NP_001193921.1	3, 4	649
	NM_005123.3	NP_005114.1	5, 6	1067
	NR_135146.1		5, 6	1067
	XM_011539042.1	XP_011537344.1	3, 4	650
GenBank mRNA	AB307699.1	-	3, 4	591
	AF478445.1	-	3, 4	649
	AK312959.1	-	5, 6	1068
	BX571749.1	-	3, 4	646
	U68233.1	-	5, 6	944

More Information

Gene Ontology Categories:

Process(es)

negative regulation of transcription from RNA polymerase II promoter
nitrogen catabolite activation of transcription from RNA polymerase II promoter
regulation of carbohydrate metabolic process
transcription initiation from RNA polymerase II promoter
inflammatory response
signal transduction
Notch signaling pathway
bile acid metabolic process
response to glucose
regulation of low-density lipoprotein particle clearance
bile acid and bile salt transport
intracellular receptor signaling pathway
response to lipopolysaccharide
toll-like receptor 4 signaling pathway
regulation of urea metabolic process
histone H3-R17 methylation
cellular triglyceride homeostasis
bile acid signaling pathway
intracellular bile acid receptor signaling pathway
negative regulation of apoptotic process
negative regulation of I-kappaB kinase/NF-kappaB signaling
steroid hormone mediated signaling pathway
innate immune response
positive regulation of transcription from RNA polymerase II promoter
digestive tract development
regulation of insulin secretion involved in cellular response to glucose stimulus
regulation of bile acid biosynthetic process
negative regulation of bile acid biosynthetic process
cellular response to fatty acid
cellular response to organonitrogen compound
interleukin-17 secretion
regulation of cholesterol metabolic process
negative regulation of interferon-gamma secretion
negative regulation of tumor necrosis factor secretion
positive regulation of glutamate metabolic process
positive regulation of ammonia assimilation cycle

Function(s)

RNA polymerase II distal enhancer sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
transcriptional activator activity, RNA polymerase II transcription factor binding
transcription factor activity, sequence-specific DNA binding
transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
steroid hormone receptor activity
transcription coactivator activity
transcription corepressor activity
RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding
thyroid hormone receptor activity
protein binding
zinc ion binding
ligand-dependent nuclear receptor binding
bile acid binding
bile acid receptor activity
peptide binding
sequence-specific DNA binding
retinoid X receptor binding
chenodeoxycholic acid binding