s22547

• Gene Symbol: NLGN1
• Gene Name: neuroligin 1
• Gene Aliases: NL1
• Chromosome Location: Chr.3: 173395899 - 174291287 on Build GRCh38
• UniGene ID: Hs.478289
• Species: Human
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: NLGN1
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_014932.3	NP_055747.1	4	1049
	XM_005247234.2	XP_005247291.1	3	1224
	XM_005247235.3	XP_005247292.1	3	1420
	XM_005247236.2	XP_005247293.1	3	1224
	XM_005247237.3	XP_005247294.1	2	1718
	XM_006713540.3	XP_006713603.1	4	1480
	XM_011512551.2	XP_011510853.1	5	1331
	XM_011512552.2	XP_011510854.1	4	1767
	XM_017005888.1	XP_016861377.1	4	1628
	XM_017005889.1	XP_016861378.1	4	1628
	XM_017005890.1	XP_016861379.1	4	1284
	XM_017005891.1	XP_016861380.1	4	1480
	XM_017005892.1	XP_016861381.1	4	1782
	XM_017005893.1	XP_016861382.1	5	1894
	XM_017005894.1	XP_016861383.1	4	3412
	XM_017005895.1	XP_016861384.1	4	7585
	XM_017005896.1	XP_016861385.1	4	1066
	XM_017005897.1	XP_016861386.1	4	1628
	XM_017005898.1	XP_016861387.1	3	1568
	XM_017005899.1	XP_016861388.1	3	1707
	XM_017005900.1	XP_016861389.1	4	1213
	XM_017005901.1	XP_016861390.1	3	1269
	XM_017005902.1	XP_016861391.1	4	1271
	XM_017005903.1	XP_016861392.1	3	1420
	XM_017005904.1	XP_016861393.1	3	1707
GenBank mRNA	AB028993.1	-	3	1289
	AK307813.1	-	5	1175
	BC032555.1	-	4	1054	5558890
	GQ489206.1	-	4	740

More Information

Other Species Targeted

This siRNA also targets the following transcripts in Rat: NM_053868, XM_008760890, U22952.
This siRNA also targets the following transcripts in Mouse: NM_001163387, NM_138666, BC005523, BC098461, AK122433.

Panther Classification:

Molecular Function -

cell adhesion molecule

Gene Ontology Categories:

Process(es)

regulation of respiratory gaseous exchange by neurological system process
protein targeting
heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
neuron cell-cell adhesion
nervous system development
synapse assembly
positive regulation of circadian sleep/wake cycle, wakefulness
synaptic vesicle targeting
calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules
neuronal signal transduction
neuron projection development
positive regulation of synaptic transmission, GABAergic
protein localization to synapse
establishment of protein localization
regulation of neuron differentiation
rhythmic process
cytoskeletal matrix organization at active zone
protein homooligomerization
protein heterotetramerization
positive regulation of filopodium assembly
positive regulation of synapse assembly
positive regulation of synaptic transmission, glutamatergic
long-term synaptic potentiation
positive regulation of dendritic spine development
negative regulation of dendritic spine morphogenesis
terminal button organization
synaptic vesicle clustering
postsynaptic membrane assembly
presynaptic membrane assembly
AMPA glutamate receptor clustering
NMDA glutamate receptor clustering
neurexin clustering involved in presynaptic membrane assembly
postsynaptic density protein 95 clustering
receptor localization to synapse
positive regulation of ruffle assembly
positive regulation of synaptic vesicle endocytosis
positive regulation of protein localization to synapse
positive regulation of intracellular signal transduction
positive regulation of synaptic vesicle exocytosis
regulation of N-methyl-D-aspartate selective glutamate receptor activity
regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity
positive regulation of excitatory postsynaptic potential
positive regulation of synaptic vesicle clustering

Function(s)

receptor activity
PDZ domain binding
neurexin family protein binding
protein dimerization activity
cell adhesion molecule binding
carboxylic ester hydrolase activity
scaffold protein binding