s2447 Validated

• Gene Symbol: CAV1
• Gene Name: caveolin 1
• Gene Aliases: BSCL3, CGL3, LCCNS, MSTP085, PPH3, VIP21
• Chromosome Location: Chr.7: 116524785 - 116561185 on Build GRCh38
• UniGene ID: Hs.74034
• Species: Human
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: CAV1
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_001172895.1	NP_001166366.1	3	1209
	NM_001172896.1	NP_001166367.1	2	644
	NM_001172897.1	NP_001166368.1	3	443
	NM_001753.4	NP_001744.2	3	720
GenBank mRNA	AB209926.1	-	2	570
	AB451284.1	-	3	442
	AB451416.1	-	3	442
	AF172085.1	-	2	584
	AK290871.1	-	3	717
	AK307501.1	-	2	576
	AY762103.1	-	3	484
	BC009685.1	-	3	515
	BC082246.1	-	3	452	5441212
	BT007143.1	-	3	442
	DA477166.1	-	3	444
	EF649773.1	-	3	438
	EF649774.1	-	2	574
	Z18951.1	-	3	476

More Information

Other Species Targeted

This siRNA also targets the following transcripts in Rat: NM_133651, NM_031556, XM_006236131, XM_006236130, Z46614, and others.

Matching Taqman Gene Expression Assay:

Hs00971716_m1

Panther Classification:

Molecular Function -

scaffold/adaptor protein

Gene Ontology Categories:

Process(es)

negative regulation of transcription from RNA polymerase II promoter
MAPK cascade
inactivation of MAPK activity
angiogenesis
vasculogenesis
response to hypoxia
negative regulation of endothelial cell proliferation
positive regulation of endothelial cell proliferation
negative regulation of cytokine-mediated signaling pathway
response to ischemia
regulation of the force of heart contraction by chemical signal
triglyceride metabolic process
calcium ion transport
cellular calcium ion homeostasis
regulation of smooth muscle contraction
skeletal muscle tissue development
response to nutrient
lactation
protein localization
response to bacterium
response to gamma radiation
positive regulation of calcium ion transport into cytosol
posttranscriptional regulation of gene expression
positive regulation of gene expression
negative regulation of muscle cell apoptotic process
positive regulation of peptidase activity
vesicle organization
receptor-mediated endocytosis of virus by host cell
regulation of fatty acid metabolic process
lipid storage
regulation of blood coagulation
cholesterol transport
negative regulation of transforming growth factor beta receptor signaling pathway
negative regulation of epithelial cell differentiation
mammary gland development
organ regeneration
positive regulation of microtubule polymerization
T cell costimulation
negative regulation of protein ubiquitination
positive regulation of protein ubiquitination
receptor internalization
negative regulation of protein binding
positive regulation of protein binding
maintenance of protein location in cell
response to progesterone
negative regulation of peptidyl-serine phosphorylation
positive regulation of peptidyl-serine phosphorylation
cholesterol efflux
nitric oxide homeostasis
positive regulation of toll-like receptor 3 signaling pathway
wound healing
vasoconstriction
response to drug
negative regulation of tyrosine phosphorylation of Stat5 protein
cholesterol homeostasis
positive regulation of catalytic activity
negative regulation of MAPK cascade
response to estrogen
protein localization to plasma membrane raft
negative regulation of nitric oxide biosynthetic process
negative regulation of neuron differentiation
positive regulation of endocytosis
positive regulation of vasoconstriction
negative regulation of JAK-STAT cascade
microtubule polymerization
negative regulation of pinocytosis
negative regulation of smooth muscle cell proliferation
leukocyte migration
regulation of nitric-oxide synthase activity
negative regulation of nitric-oxide synthase activity
protein homooligomerization
response to glucocorticoid
regulation of cytosolic calcium ion concentration
response to calcium ion
membrane depolarization
regulation of peptidase activity
calcium ion homeostasis
mammary gland involution
positive regulation of cell adhesion molecule production
negative regulation of necroptotic process
negative regulation of protein tyrosine kinase activity
negative regulation of ERK1 and ERK2 cascade
caveola assembly
cellular response to mechanical stimulus
cellular response to exogenous dsRNA
cellular response to peptide hormone stimulus
cellular response to hyperoxia
cellular response to transforming growth factor beta stimulus
caveolin-mediated endocytosis
regulation of heart rate by cardiac conduction
angiotensin-activated signaling pathway involved in heart process
negative regulation of canonical Wnt signaling pathway
positive regulation of canonical Wnt signaling pathway
cellular senescence
apoptotic signaling pathway
regulation of membrane repolarization during action potential
regulation of cardiac muscle cell action potential involved in regulation of contraction
regulation of ventricular cardiac muscle cell action potential
regulation of ruffle assembly
negative regulation of peptidyl-tyrosine autophosphorylation
negative regulation of potassium ion transmembrane transport
regulation of cell communication by electrical coupling involved in cardiac conduction
regulation of inward rectifier potassium channel activity
positive regulation of ER-associated ubiquitin-dependent protein catabolic process
protein localization to basolateral plasma membrane
positive regulation of gap junction assembly
beta-catenin destruction complex disassembly
receptor internalization involved in canonical Wnt signaling pathway
regulation of entry of bacterium into host cell
negative regulation of anoikis
positive regulation of extrinsic apoptotic signaling pathway
positive regulation of intrinsic apoptotic signaling pathway
negative regulation of cation channel activity

Function(s)

RNA polymerase I transcription factor binding
receptor binding
patched binding
structural molecule activity
protein binding
cholesterol binding
peptidase activator activity
enzyme binding
protein kinase binding
syntaxin binding
protein binding, bridging
protein complex scaffold
identical protein binding
ion channel binding
protein heterodimerization activity
Rac GTPase binding
nitric-oxide synthase binding
ATPase binding
inward rectifier potassium channel inhibitor activity
MDM2/MDM4 family protein binding