s25931

• Gene Symbol: AGO2
• Gene Name: argonaute 2, RISC catalytic component
• Gene Aliases: EIF2C2, Q10
• Chromosome Location: Chr.8: 140520158 - 140642406 on Build GRCh38
• UniGene ID: Hs.743313
• Species: Human
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: AGO2
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_001164623.1	NP_001158095.1	6, 7	839
	NM_012154.3	NP_036286.2	6, 7	839
	XM_011516965.2	XP_011515267.1	6, 7	3915
	XM_011516966.2	XP_011515268.1	6, 7	1656
	XM_011516968.2	XP_011515270.2	6, 7	990
	XM_017013317.1	XP_016868806.1	5, 6	608
GenBank mRNA	AY077717.1	-	4, 5	777
	BC018727.1	-	1, 2	86
	BC125213.1	-	5, 6	645

More Information

Other Species Targeted

This siRNA also targets the following transcripts in Rat: NM_021597, AF195534.
This siRNA also targets the following transcripts in Mouse: NM_153178, AB081472, BC128379, BC129922, BC096465, and others.

Panther Classification:

Molecular Function -

translation initiation factor

Gene Ontology Categories:

Process(es)

transcription, DNA-templated
translation
translational initiation
Wnt signaling pathway, calcium modulating pathway
post-embryonic development
RNA secondary structure unwinding
miRNA metabolic process
gene silencing by RNA
pre-miRNA processing
siRNA loading onto RISC involved in RNA interference
posttranscriptional gene silencing by RNA
production of miRNAs involved in gene silencing by miRNA
miRNA mediated inhibition of translation
mRNA cleavage involved in gene silencing by miRNA
miRNA loading onto RISC involved in gene silencing by miRNA
positive regulation of transcription from RNA polymerase II promoter
negative regulation of translational initiation
phosphatidylinositol-mediated signaling
positive regulation of nuclear-transcribed mRNA poly(A) tail shortening
RNA phosphodiester bond hydrolysis, endonucleolytic
mRNA cleavage involved in gene silencing by siRNA
positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

Function(s)

RNA 7-methylguanosine cap binding
RNA polymerase II core binding
core promoter binding
double-stranded RNA binding
single-stranded RNA binding
mRNA binding
translation initiation factor activity
endoribonuclease activity
protein binding
protein C-terminus binding
siRNA binding
miRNA binding
poly(A) RNA binding
metal ion binding
endoribonuclease activity, cleaving siRNA-paired mRNA
endoribonuclease activity, cleaving miRNA-paired mRNA