s29231 Validated

• Gene Symbol: EGLN1
• Gene Name: egl-9 family hypoxia inducible factor 1
• Gene Aliases: C1orf12, ECYT3, HALAH, HIF-PH2, HIFPH2, HPH-2, HPH2, PHD2, SM20, ZMYND6
• Chromosome Location: Chr.1: 231363751 - 231425044 on Build GRCh38
• UniGene ID: Hs.444450
• Species: Human
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: EGLN1
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_022051.2	NP_071334.1	5	4390
	XM_005273166.4	XP_005273223.1	4	1604
	XM_005273167.4	XP_005273224.1	4	1539
GenBank mRNA	AF229245.1	-	5	4390
	AF277174.1	-	5	348
	AJ310543.1	-	5	1330
	AL833885.1	-	5	758
	BC005369.1	-	5	422
	DQ975380.1	-	5	479

More Information

Other Species Targeted

This siRNA also targets the following transcripts in Rat: XM_008759848, XM_008772679, BC081694, AY228140.
This siRNA also targets the following transcripts in Mouse: NM_053207, BC083146, BC006903, AJ310546, AF453878.

Matching Taqman Gene Expression Assay:

Hs00254392_m1

Gene Ontology Categories:

Process(es)

response to hypoxia
peptidyl-proline hydroxylation to 4-hydroxy-L-proline
negative regulation of cAMP catabolic process
oxygen homeostasis
negative regulation of sequence-specific DNA binding transcription factor activity
regulation of angiogenesis
negative regulation of cyclic-nucleotide phosphodiesterase activity
cardiac muscle tissue morphogenesis
oxidation-reduction process
heart trabecula formation
ventricular septum morphogenesis
labyrinthine layer development
regulation of transcription from RNA polymerase II promoter in response to hypoxia
response to nitric oxide

Function(s)

iron ion binding
protein binding
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
enzyme binding
L-ascorbic acid binding
peptidyl-proline dioxygenase activity
peptidyl-proline 4-dioxygenase activity