s35168 Validated

• Gene Symbol: PINK1
• Gene Name: PTEN induced putative kinase 1
• Gene Aliases: BRPK, PARK6
• Chromosome Location: Chr.1: 20633455 - 20651511 on Build GRCh38
• UniGene ID: Hs.389171
• Species: Human
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: PINK1
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_032409.2	NP_115785.1	3, 4	862
GenBank mRNA	AB053323.1	-	3, 4	862
	AF316873.1	-	3, 4	838
	AK130746.1	-	1, 2	965
	BC028215.1	-	3, 4	777	5214483

More Information

Matching Taqman Gene Expression Assay:

Hs00260868_m1

Panther Classification:

Molecular Function -

non-receptor serine/threonine protein kinase, protein modifying enzyme

Gene Ontology Categories:

Process(es)

mitophagy
positive regulation of protein phosphorylation
regulation of oxidative phosphorylation
protein phosphorylation
ubiquitin-dependent protein catabolic process
response to stress
response to oxidative stress
mitochondrion organization
regulation of hydrogen peroxide metabolic process
negative regulation of gene expression
regulation of mitochondrion organization
positive regulation of peptidase activity
macroautophagy
positive regulation of macroautophagy
negative regulation of macroautophagy
phosphorylation
protein ubiquitination
peptidyl-serine phosphorylation
respiratory electron transport chain
regulation of protein ubiquitination
positive regulation of protein ubiquitination
activation of protein kinase B activity
positive regulation of synaptic transmission, dopaminergic
positive regulation of peptidyl-serine phosphorylation
positive regulation of dopamine secretion
cellular response to oxidative stress
positive regulation of protein dephosphorylation
intracellular signal transduction
peptidyl-serine autophosphorylation
TORC2 signaling
positive regulation of I-kappaB kinase/NF-kappaB signaling
regulation of protein complex assembly
negative regulation of neuron apoptotic process
positive regulation of translation
negative regulation of JNK cascade
protein stabilization
positive regulation of sequence-specific DNA binding transcription factor activity
positive regulation of ubiquitin-protein transferase activity
regulation of mitochondrial membrane potential
positive regulation of protein kinase B signaling
regulation of proteasomal protein catabolic process
cellular response to hypoxia
establishment of protein localization to mitochondrion
maintenance of protein location in mitochondrion
positive regulation of mitochondrial fission
positive regulation of release of cytochrome c from mitochondria
negative regulation of mitochondrial fission
cellular response to toxic substance
mitophagy in response to mitochondrial depolarization
regulation of synaptic vesicle transport
negative regulation of autophagosome assembly
positive regulation of mitochondrial electron transport, NADH to ubiquinone
regulation of mitophagy
negative regulation of mitophagy
negative regulation of oxidative stress-induced cell death
negative regulation of oxidative stress-induced neuron death
regulation of protein targeting to mitochondrion
negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway
negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway
negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide
positive regulation of cristae formation
positive regulation of protein targeting to mitochondrion
positive regulation of free ubiquitin chain polymerization
regulation of reactive oxygen species metabolic process
negative regulation of reactive oxygen species metabolic process
positive regulation of ATP biosynthetic process

Function(s)

magnesium ion binding
protease binding
protein kinase activity
protein serine/threonine kinase activity
protein binding
ATP binding
calcium-dependent protein kinase activity
kinase activity
peptidase activator activity
ubiquitin protein ligase binding
protein kinase B binding
C3HC4-type RING finger domain binding