s3988

Gene Symbol:

AKR1C1 AKR1C2 AKR1C3

Gene Name:

aldo-keto reductase family 1 member C1

aldo-keto reductase family 1, member C2

aldo-keto reductase family 1, member C3

Gene Aliases:

2-ALPHA-HSD, 20-ALPHA-HSD, C9, DD1, DD1/DD2, DDH, DDH1, H-37, HAKRC, HBAB, MBAB

AKR1C-pseudo, BABP, DD, DD-2, DD/BABP, DD2, DDH2, HAKRD, HBAB, MCDR2, SRXY8, TDD

DD3, DDX, HA1753, HAKRB, HAKRe, HSD17B5, PGFS, hluPGFS

Chromosome Location:

Chr.10: 4963262 - 4979967 on Build GRCh38

Chromosome Location:

Chr.10: 4987775 - 5018033 on Build GRCh38

Chromosome Location:

Chr.10: 5048766 - 5107686 on Build GRCh38

UniGene ID:

Hs.460260

Hs.460260

Hs.78183

Species:

Human

Species Specific ID (Flybase ID):

-

-

-

siRNA Details

Gene Symbol: AKR1C1
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_001353.5	NP_001344.2	1, 2	271
	XM_017015791.1	XP_016871280.1	1, 2	141
GenBank mRNA	AB031083.1	-	1, 2	88
	AK303435.1	-	1, 2	114
	AK310658.1	-	1, 2	118
	BC015490.2	-	1, 2	105	3877178
	BC020216.1	-	1, 2	104	4662654
	BC040210.1	-	6, 7	930	4825338
	BM923712.1	-	1, 2	120
	BT007197.1	-	1, 2	88
	CB119749.1	-	1, 2	87
	D26124.1	-	1, 2	39
	M86609.1	-	1, 2	94
	S68290.1	-	1, 2	79
	U05684.1	-	1, 2	91

Gene Symbol: AKR1C2
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_001135241.2	NP_001128713.1	1, 2	267
	NM_001321027.1	NP_001307956.1	1, 2	267
	NM_001354.5	NP_001345.1	3, 4	501
	NM_205845.2	NP_995317.1	2, 3	401
GenBank mRNA	AB021654.1	-	1, 2	88
	AB031084.1	-	1, 2	88
	AB209017.1	-	1, 2	155
	AK091194.1	-	3, 4	483
	AK290304.1	-	1, 2	144
	AK296419.1	-	1, 2	116
	AK296686.1	-	1, 2	114
	AK308385.1	-	1, 2	115
	BC007024.1	-	1, 2	110	3681970
	BC063574.1	-	2, 3	368	3877666
	BT006653.1	-	1, 2	88
	DA438648.1	-	2, 3	373
	DA458030.1	-	3, 4	396
	M33376.1	-	1, 2	43
	S68330.1	-	1, 2	94
	U05598.1	-	1, 2	111

Gene Symbol: AKR1C3
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
GenBank mRNA	DQ269985.1	-	1, 2	88

More Information

Panther Classification:

Molecular Function -

oxidoreductase, reductase, metabolite interconversion enzyme

Gene Ontology Categories:

Process(es)

retinoid metabolic process
xenobiotic metabolic process
digestion
bile acid metabolic process
bile acid and bile salt transport
intestinal cholesterol absorption
epithelial cell differentiation
progesterone metabolic process
retinal metabolic process
cholesterol homeostasis
daunorubicin metabolic process
doxorubicin metabolic process
response to organophosphorus
protein homooligomerization
oxidation-reduction process
cellular response to jasmonic acid stimulus
prostaglandin metabolic process
G-protein coupled receptor signaling pathway
steroid metabolic process
positive regulation of cell proliferation
positive regulation of protein kinase B signaling
cellular response to prostaglandin D stimulus

Function(s)

alditol:NADP+ 1-oxidoreductase activity
aldo-keto reductase (NADP) activity
protein binding
oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor
phenanthrene 9,10-monooxygenase activity
carboxylic acid binding
bile acid binding
17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity
androsterone dehydrogenase (B-specific) activity
ketosteroid monooxygenase activity
trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity
indanol dehydrogenase activity