s3989

Gene Symbol:

AKR1C1 AKR1C2

Gene Name:

aldo-keto reductase family 1 member C1

aldo-keto reductase family 1, member C2

Gene Aliases:

2-ALPHA-HSD, 20-ALPHA-HSD, C9, DD1, DD1/DD2, DDH, DDH1, H-37, HAKRC, HBAB, MBAB

AKR1C-pseudo, BABP, DD, DD-2, DD/BABP, DD2, DDH2, HAKRD, HBAB, MCDR2, SRXY8, TDD

Chromosome Location:

Chr.10: 4963262 - 4979967 on Build GRCh38

Chromosome Location:

Chr.10: 4987775 - 5018033 on Build GRCh38

UniGene ID:

Hs.460260

Hs.460260

Species:

Human

Species Specific ID (Flybase ID):

-

-

siRNA Details

Gene Symbol: AKR1C1
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_001353.5	NP_001344.2	8	1050
	XM_017015791.1	XP_016871280.1	7	842
GenBank mRNA	AB031083.1	-	8	867
	BC015490.2	-	8	884	3877178
	BC020216.1	-	8	883	4662654
	BC040210.1	-	13	1709	4825338
	BT007197.1	-	8	867
	D26124.1	-	8	818
	M86609.1	-	8	873
	S68290.1	-	8	858
	U05684.1	-	8	870

Gene Symbol: AKR1C2
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_001321027.1	NP_001307956.1	7	968
	NM_001354.5	NP_001345.1	10	1280
	NM_205845.2	NP_995317.1	9	1180
GenBank mRNA	AB021654.1	-	8	867
	AB031084.1	-	8	867
	AB209017.1	-	8	935
	AK091194.1	-	9	2534
	AK290304.1	-	8	923
	AK296419.1	-	7	817
	AK308385.1	-	7	815
	BC007024.1	-	8	889	3681970
	BC063574.1	-	9	1147	3877666
	BT006653.1	-	8	867
	M33376.1	-	8	822
	S68330.1	-	8	873
	U05598.1	-	8	890

More Information

Panther Classification:

Molecular Function -

oxidoreductase, reductase, metabolite interconversion enzyme

Gene Ontology Categories:

Process(es)

retinoid metabolic process
xenobiotic metabolic process
digestion
bile acid metabolic process
bile acid and bile salt transport
intestinal cholesterol absorption
epithelial cell differentiation
progesterone metabolic process
retinal metabolic process
cholesterol homeostasis
daunorubicin metabolic process
doxorubicin metabolic process
response to organophosphorus
protein homooligomerization
oxidation-reduction process
cellular response to jasmonic acid stimulus
prostaglandin metabolic process
G-protein coupled receptor signaling pathway
steroid metabolic process
positive regulation of cell proliferation
positive regulation of protein kinase B signaling
cellular response to prostaglandin D stimulus

Function(s)

alditol:NADP+ 1-oxidoreductase activity
aldo-keto reductase (NADP) activity
protein binding
oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor
phenanthrene 9,10-monooxygenase activity
carboxylic acid binding
bile acid binding
17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity
androsterone dehydrogenase (B-specific) activity
ketosteroid monooxygenase activity
trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity
indanol dehydrogenase activity