s3990

Gene Symbol:

AKR1C1 AKR1C2

Gene Name:

aldo-keto reductase family 1 member C1

aldo-keto reductase family 1, member C2

Gene Aliases:

2-ALPHA-HSD, 20-ALPHA-HSD, C9, DD1, DD1/DD2, DDH, DDH1, H-37, HAKRC, HBAB, MBAB

AKR1C-pseudo, BABP, DD, DD-2, DD/BABP, DD2, DDH2, HAKRD, HBAB, MCDR2, SRXY8, TDD

Chromosome Location:

Chr.10: 4963262 - 4979967 on Build GRCh38

Chromosome Location:

Chr.10: 4987775 - 5018033 on Build GRCh38

UniGene ID:

Hs.460260

Hs.460260

Species:

Human

Species Specific ID (Flybase ID):

-

-

siRNA Details

Gene Symbol: AKR1C1
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_001353.5	NP_001344.2	8	1092
	XM_017015791.1	XP_016871280.1	7	884
GenBank mRNA	AB031083.1	-	8	909
	BC015490.2	-	8	926	3877178
	BC020216.1	-	8	925	4662654
	BC040210.1	-	13	1751	4825338
	BT007197.1	-	8	909
	D26124.1	-	8	860
	M86609.1	-	8	915
	S68290.1	-	8	900
	U05684.1	-	8	912

Gene Symbol: AKR1C2
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_001321027.1	NP_001307956.1	7	1010
	NM_001354.5	NP_001345.1	10	1322
	NM_205845.2	NP_995317.1	9	1222
GenBank mRNA	AB021654.1	-	8	909
	AB031084.1	-	8	909
	AB209017.1	-	8	977
	AK091194.1	-	9	2576
	AK290304.1	-	8	965
	AK296419.1	-	7	859
	AK308385.1	-	7	857
	BC007024.1	-	8	931	3681970
	BC063574.1	-	9	1189	3877666
	BT006653.1	-	8	909
	M33376.1	-	8	864
	S68330.1	-	8	915
	U05598.1	-	8	932

More Information

Panther Classification:

Molecular Function -

oxidoreductase, reductase, metabolite interconversion enzyme

Gene Ontology Categories:

Process(es)

retinoid metabolic process
xenobiotic metabolic process
digestion
bile acid metabolic process
bile acid and bile salt transport
intestinal cholesterol absorption
epithelial cell differentiation
progesterone metabolic process
retinal metabolic process
cholesterol homeostasis
daunorubicin metabolic process
doxorubicin metabolic process
response to organophosphorus
protein homooligomerization
oxidation-reduction process
cellular response to jasmonic acid stimulus
prostaglandin metabolic process
G-protein coupled receptor signaling pathway
steroid metabolic process
positive regulation of cell proliferation
positive regulation of protein kinase B signaling
cellular response to prostaglandin D stimulus

Function(s)

alditol:NADP+ 1-oxidoreductase activity
aldo-keto reductase (NADP) activity
protein binding
oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor
phenanthrene 9,10-monooxygenase activity
carboxylic acid binding
bile acid binding
17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity
androsterone dehydrogenase (B-specific) activity
ketosteroid monooxygenase activity
trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity
indanol dehydrogenase activity