s4217 Validated

• Gene Symbol: DNMT1
• Gene Name: DNA (cytosine-5-)-methyltransferase 1
• Gene Aliases: ADCADN, AIM, CXXC9, DNMT, HSN1E, MCMT, m.HsaI
• Chromosome Location: Chr.19: 10133344 - 10195135 on Build GRCh38
• UniGene ID: Hs.202672
• Species: Human
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: DNMT1
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_001130823.2	NP_001124295.1	7, 8	892
	NM_001318730.1	NP_001305659.1	6, 7	763
	NM_001318731.1	NP_001305660.1	7, 8	771
	NM_001379.3	NP_001370.1	6, 7	844
GenBank mRNA	AB209413.2	-	6, 7	570
	AF180682.1	-	4, 5	351
	BC092517.1	-	7, 8	651	3077831
	BC126227.1	-	7, 8	836	8991943
	BC144093.1	-	7, 8	836	9052613
	X63692.1	-	6, 7	845

More Information

Matching Taqman Gene Expression Assay:

Hs00154749_m1

Panther Classification:

Molecular Function -

DNA metabolism protein, DNA methyltransferase, nucleic acid metabolism protein

Gene Ontology Categories:

Process(es)

negative regulation of transcription from RNA polymerase II promoter
DNA methylation
transcription, DNA-templated
Ras protein signal transduction
brain development
aging
response to heat
response to toxic substance
response to ionizing radiation
maintenance of DNA methylation
DNA methylation on cytosine within a CG sequence
positive regulation of gene expression
response to activity
gene silencing
covalent chromatin modification
neuron differentiation
response to caffeine
response to estradiol
response to lipopolysaccharide
response to vitamin A
response to testosterone
cellular response to platelet-derived growth factor stimulus
response to antidepressant
regulation of cell proliferation
DNA hypermethylation
response to ethanol
negative regulation of gene expression, epigenetic
S-adenosylhomocysteine metabolic process
S-adenosylmethioninamine metabolic process
S-adenosylmethionine metabolic process
positive regulation of histone H3-K4 methylation
negative regulation of histone H3-K9 methylation
cellular response to amino acid stimulus
cellular response to lead ion
cellular response to transforming growth factor beta stimulus
C-5 methylation of cytosine
positive regulation of methylation-dependent chromatin silencing
cellular response to nerve growth factor stimulus

Function(s)

DNA binding
double-stranded DNA binding
RNA binding
DNA (cytosine-5-)-methyltransferase activity
protein binding
zinc ion binding
methyl-CpG binding
DNA-methyltransferase activity
protein domain specific binding
estrogen receptor binding
histone deacetylase binding
unmethylated CpG binding
DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates
promoter-specific chromatin binding