s450 Validated

• Gene Symbol: PLK1
• Gene Name: polo like kinase 1
• Gene Aliases: PLK, STPK13
• Chromosome Location: Chr.16: 23678772 - 23690367 on Build GRCh38
• UniGene ID: Hs.592049
• Species: Human
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: PLK1
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_005030.5	NP_005021.2	9	1617
GenBank mRNA	AB209179.1	-	8	3476
	AK303263.1	-	10	1233
	AK313227.1	-	9	1541
	BC002369.2	-	9	1509	2822226
	BC003002.1	-	9	1487	2823623
	BC014846.1	-	9	1462	3854860
	L19559.1	-	9	1519
	U01038.1	-	9	1519
	X73458.1	-	9	1533
	X75932.1	-	9	1519

More Information

Matching Taqman Gene Expression Assay:

Hs00153444_m1

Panther Classification:

Molecular Function -

non-receptor serine/threonine protein kinase, protein modifying enzyme

Gene Ontology Categories:

Process(es)

mitotic sister chromatid segregation
G2/M transition of mitotic cell cycle
negative regulation of transcription from RNA polymerase II promoter
mitotic cytokinesis
cytokinesis
microtubule bundle formation
protein phosphorylation
sister chromatid cohesion
mitotic nuclear division
mitotic nuclear envelope disassembly
mitotic spindle assembly checkpoint
regulation of mitotic cell cycle
cell proliferation
positive regulation of peptidyl-threonine phosphorylation
female meiosis chromosome segregation
protein ubiquitination
peptidyl-serine phosphorylation
regulation of mitotic metaphase/anaphase transition
anaphase-promoting complex-dependent catabolic process
G2 DNA damage checkpoint
protein destabilization
positive regulation of proteasomal ubiquitin-dependent protein catabolic process
protein ubiquitination involved in ubiquitin-dependent protein catabolic process
negative regulation of apoptotic process
regulation of protein binding
homologous chromosome segregation
establishment of protein localization
negative regulation of cyclin-dependent protein serine/threonine kinase activity
positive regulation of proteolysis
centrosome organization
positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition
regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
positive regulation of ubiquitin-protein transferase activity
regulation of cell cycle
synaptonemal complex disassembly
protein localization to chromatin
positive regulation of protein localization to nucleus
regulation of mitotic spindle assembly
regulation of cell cycle G2/M phase transition
positive regulation of ubiquitin protein ligase activity

Function(s)

protein kinase activity
protein serine/threonine kinase activity
protein binding
ATP binding
microtubule binding
anaphase-promoting complex binding
kinase activity
protein kinase binding