s459 Validated

• Gene Symbol: BRCA1
• Gene Name: BRCA1, DNA repair associated
• Gene Aliases: BRCAI, BRCC1, BROVCA1, FANCS, IRIS, PNCA4, PPP1R53, PSCP, RNF53
• Chromosome Location: Chr.17: 43044295 - 43125483 on Build GRCh38
• UniGene ID: Hs.194143
• Species: Human
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: BRCA1
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_007294.3	NP_009225.1	12	4437
	NM_007297.3	NP_009228.2	11	4345
	NM_007298.3	NP_009229.2	11	915
	NM_007299.3	NP_009230.2	12	1090
	NM_007300.3	NP_009231.2	12	4437
	NR_027676.1		12	4341
GenBank mRNA	AF005068.1	-	12	4306
	AK316200.1	-	11	987
	AY751490.1	-	11	4205
	BC046142.1	-	6	521
	BC072418.1	-	12	1090
	BC085615.1	-	12	995
	BC115037.1	-	12	4342	7961446
	JN686490.1	-	11	4205
	U14680.1	-	12	4324
	U64805.1	-	11	896

More Information

Matching Taqman Gene Expression Assay:

Hs00173233_m1

Panther Classification:

Molecular Function -

ubiquitin-protein ligase, protein modifying enzyme

Gene Ontology Categories:

Process(es)

double-strand break repair via homologous recombination
DNA double-strand break processing
DNA synthesis involved in DNA repair
strand displacement
DNA replication
postreplication repair
double-strand break repair
double-strand break repair via nonhomologous end joining
regulation of gene expression by genetic imprinting
transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
regulation of transcription from RNA polymerase III promoter
fatty acid biosynthetic process
apoptotic process
cellular response to DNA damage stimulus
DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
chromosome segregation
centrosome cycle
brain development
response to nutrient
intrinsic apoptotic signaling pathway in response to DNA damage
dosage compensation by inactivation of X chromosome
response to ionizing radiation
positive regulation of vascular endothelial growth factor production
positive regulation of gene expression
protein ubiquitination
protein sumoylation
androgen receptor signaling pathway
chromosome breakage
positive regulation of protein ubiquitination
G2 DNA damage checkpoint
response to estradiol
negative regulation of intracellular estrogen receptor signaling pathway
positive regulation of protein import into nucleus, translocation
positive regulation of histone acetylation
negative regulation of histone acetylation
regulation of cell proliferation
regulation of apoptotic process
chordate embryonic development
response to estrogen
regulation of DNA methylation
negative regulation of fatty acid biosynthetic process
positive regulation of DNA repair
positive regulation of angiogenesis
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
negative regulation of centriole replication
positive regulation of histone H3-K4 methylation
negative regulation of histone H3-K4 methylation
negative regulation of histone H3-K9 methylation
positive regulation of histone H3-K9 methylation
protein autoubiquitination
positive regulation of histone H4-K20 methylation
positive regulation of cell cycle arrest
cellular response to tumor necrosis factor
cellular response to indole-3-methanol
protein K6-linked ubiquitination
regulation of signal transduction by p53 class mediator
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
negative regulation of reactive oxygen species metabolic process
positive regulation of histone H3-K9 acetylation
positive regulation of histone H4-K16 acetylation

Function(s)

DNA binding
chromatin binding
damaged DNA binding
transcription coactivator activity
RNA binding
ubiquitin-protein transferase activity
protein binding
zinc ion binding
tubulin binding
ligase activity
enzyme binding
ubiquitin protein ligase binding
transcription regulatory region DNA binding
androgen receptor binding