s4917

• Gene Symbol: EZH2
• Gene Name: enhancer of zeste 2 polycomb repressive complex 2 subunit
• Gene Aliases: ENX-1, ENX1, EZH1, EZH2b, KMT6, KMT6A, WVS, WVS2
• Chromosome Location: Chr.7: 148807372 - 148884662 on Build GRCh38
• UniGene ID: Hs.444082
• Species: Human
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: EZH2
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_001203247.1	NP_001190176.1	11, 12	1597
	NM_001203248.1	NP_001190177.1	11, 12	1570
	NM_001203249.1	NP_001190178.1	11, 12	1697
	NM_004456.4	NP_004447.2	11, 12	1612
	NM_152998.2	NP_694543.1	10, 11	1480
	XM_005249962.4	XP_005250019.1	11, 12	4038
	XM_005249963.4	XP_005250020.1	11, 12	4011
	XM_005249964.4	XP_005250021.1	11, 12	4012
	XM_011515883.2	XP_011514185.1	12, 13	1587
	XM_011515884.2	XP_011514186.1	11, 12	1719
	XM_011515885.2	XP_011514187.1	11, 12	4028
	XM_011515886.2	XP_011514188.1	12, 13	1736
	XM_011515887.2	XP_011514189.1	11, 12	1585
	XM_011515888.2	XP_011514190.1	11, 12	1707
	XM_011515889.2	XP_011514191.1	11, 12	1509
	XM_011515890.2	XP_011514192.1	10, 11	3938
	XM_011515891.2	XP_011514193.1	9, 10	1672
	XM_011515892.2	XP_011514194.1	11, 12	4056
	XM_011515893.2	XP_011514195.1	10, 11	3921
	XM_011515894.2	XP_011514196.1	10, 11	1437
	XM_011515895.2	XP_011514197.1	10, 11	3911
	XM_011515896.2	XP_011514198.1	10, 11	3922
	XM_011515897.2	XP_011514199.1	12, 13	1763
	XM_011515898.2	XP_011514200.1	12, 13	1690
	XM_011515899.2	XP_011514201.1	11, 12	4058
	XM_017011817.1	XP_016867306.1	11, 12	4054
	XM_017011818.1	XP_016867307.1	12, 13	1721
	XM_017011819.1	XP_016867308.1	11, 12	4039
	XM_017011820.1	XP_016867309.1	10, 11	1468
	XM_017011821.1	XP_016867310.1	12, 13	1748
GenBank mRNA	AB208895.1	-	11	2541
	AK092676.1	-	10, 11	1379
	AK293239.1	-	11, 12	1508
	AK302216.1	-	11, 12	1697
	AK314291.1	-	10, 11	1422
	BC010858.2	-	11, 12	1541	3901250
	JF327843.1	-	9, 10	1287
	U61145.1	-	11, 12	1493
	X95653.1	-	11, 12	1461

More Information

Other Species Targeted

This siRNA also targets the following transcripts in Rat: NM_001134979, XM_006236404, XM_006236408, XM_006236403, XM_006236405, and others.
This siRNA also targets the following transcripts in Mouse: NM_007971, NM_001146689, BC016391, BC003772, U52951, and others.

Panther Classification:

Molecular Function -

histone modifying enzyme

Gene Ontology Categories:

Process(es)

negative regulation of transcription from RNA polymerase II promoter
DNA methylation
chromatin organization
transcription, DNA-templated
regulation of transcription, DNA-templated
positive regulation of epithelial to mesenchymal transition
regulation of gliogenesis
skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration
cerebellar cortex development
hippocampus development
response to estradiol
negative regulation of transcription elongation from RNA polymerase II promoter
regulation of cell proliferation
regulation of circadian rhythm
positive regulation of MAP kinase activity
negative regulation of sequence-specific DNA binding transcription factor activity
positive regulation of GTPase activity
negative regulation of epidermal cell differentiation
negative regulation of gene expression, epigenetic
negative regulation of transcription, DNA-templated
negative regulation of retinoic acid receptor signaling pathway
rhythmic process
negative regulation of striated muscle cell differentiation
cellular response to hydrogen peroxide
G1 to G0 transition
histone H3-K27 methylation
protein localization to chromatin
positive regulation of protein serine/threonine kinase activity
positive regulation of dendrite development
negative regulation of G1/S transition of mitotic cell cycle

Function(s)

core promoter binding
DNA binding
chromatin binding
RNA binding
protein binding
protein-lysine N-methyltransferase activity
histone-lysine N-methyltransferase activity
chromatin DNA binding
histone methyltransferase activity
ribonucleoprotein complex binding
sequence-specific DNA binding
histone methyltransferase activity (H3-K27 specific)
promoter-specific chromatin binding