s532997

• Gene Symbol: RUNX2
• Gene Name: runt related transcription factor 2
• Gene Aliases: AML3, CBF-alpha-1, CBFA1, CCD, CCD1, CLCD, OSF-2, OSF2, PEA2aA, PEBP2aA
• Chromosome Location: Chr.6: 45328142 - 45664032 on Build GRCh38
• UniGene ID: Hs.535845
• Species: Human
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: RUNX2
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_001015051.3	NP_001015051.3	1	17
	NM_001024630.3	NP_001019801.3	1	17
	NR_103532.1		1	17
	NR_103533.1		1	17
	XM_011514960.2	XP_011513262.1	1	192
	XM_011514961.2	XP_011513263.1	1	192
	XM_011514962.2	XP_011513264.1	1	192
	XM_011514963.2	XP_011513265.1	1	192
	XM_011514964.2	XP_011513266.1	1	192
	XM_011514965.2	XP_011513267.1	1	192
	XM_017011391.1	XP_016866880.1	1	192
	XM_017011393.1	XP_016866882.1	1	192
	XM_017011394.1	XP_016866883.1	1	192
	XM_017011395.1	XP_016866884.1	1	192
GenBank mRNA	AF053952.1	-		11

More Information

Other Species Targeted

This siRNA also targets the following transcripts in Rat: AF053953.
This siRNA also targets the following transcripts in Mouse: NR_073392, AF053954, DQ458792, AF020681, AF053951, and others.

Panther Classification:

Molecular Function -

Runt transcription factor

Gene Ontology Categories:

Process(es)

ossification
osteoblast differentiation
endochondral ossification
osteoblast fate commitment
chondrocyte differentiation
chondrocyte development
osteoblast development
regulation of transcription from RNA polymerase II promoter
transcription from RNA polymerase II promoter
positive regulation of cell proliferation
hemopoiesis
neuron differentiation
T cell differentiation
BMP signaling pathway
positive regulation of chondrocyte differentiation
embryonic forelimb morphogenesis
regulation of fibroblast growth factor receptor signaling pathway
odontogenesis of dentin-containing tooth
regulation of odontogenesis of dentin-containing tooth
cellular response to fibroblast growth factor stimulus
regulation of cell differentiation
positive regulation of osteoblast differentiation
negative regulation of smoothened signaling pathway
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
cell maturation
embryonic cranial skeleton morphogenesis
stem cell differentiation
cellular response to BMP stimulus
positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus

Function(s)

RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II core promoter sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
chromatin binding
transcription factor activity, sequence-specific DNA binding
protein binding
ATP binding
protein domain specific binding
histone deacetylase binding
bHLH transcription factor binding
repressing transcription factor binding