s536590

• Gene Symbol: HFE
• Gene Name: hemochromatosis
• Gene Aliases: HFE1, HH, HLA-H, MVCD7, TFQTL2
• Chromosome Location: Chr.6: 26087281 - 26096216 on Build GRCh38
• UniGene ID: Hs.233325
• Species: Human
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: HFE
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_000410.3	NP_000401.1	4	918
	NM_001300749.1	NP_001287678.1	4	918
	NM_139003.2	NP_620572.1	3	600
	NM_139004.2	NP_620573.1	3	642
	NM_139006.2	NP_620575.1	4	876
	NM_139007.2	NP_620576.1	3	654
	NM_139008.2	NP_620577.1	3	612
	NM_139009.2	NP_620578.1	4	849
	NM_139010.2	NP_620579.1	2	378
	XM_011514543.2	XP_011512845.1	4	880
GenBank mRNA	AF079407.1	-	4	752
	AF079408.1	-	3	530
	AF079409.1	-	3	488
	AF115265.1	-	4	769
	AF144240.1	-	2	427
	AF149804.1	-	3	484
	AJ249335.1	-	4	849
	AJ249336.1	-	3	654
	AJ249337.1	-	3	642
	AJ250635.1	-	2	378
	AK293393.1	-	3	979
	AK300933.1	-	4	762
	AK316502.1	-	4	931
	AY205604.1	-	3	519
	BC074721.2	-	5	798	30915171
	BC117201.1	-	4	793	40125752
	BC117203.1	-	4	793	40125754
	U60319.1	-	4	979

More Information

Panther Classification:

Molecular Function -

major histocompatibility complex protein

Gene Ontology Categories:

Process(es)

antigen processing and presentation of peptide antigen via MHC class I
negative regulation of T cell antigen processing and presentation
negative regulation of T cell cytokine production
protein complex assembly
cellular iron ion homeostasis
acute-phase response
immune response
female pregnancy
response to iron ion
cellular response to iron ion starvation
positive regulation of gene expression
positive regulation of pathway-restricted SMAD protein phosphorylation
antigen processing and presentation
BMP signaling pathway
positive regulation of protein binding
negative regulation of proteasomal ubiquitin-dependent protein catabolic process
hormone biosynthetic process
positive regulation of receptor-mediated endocytosis
iron ion homeostasis
multicellular organismal iron ion homeostasis
cellular response to iron ion
positive regulation of peptide hormone secretion
liver regeneration
iron ion import into cell
negative regulation of receptor binding
positive regulation of receptor binding
positive regulation of ferrous iron import into cell
negative regulation of antigen processing and presentation of endogenous peptide antigen via MHC class I
positive regulation of ferrous iron binding
positive regulation of transferrin receptor binding
response to iron ion starvation
regulation of protein localization to cell surface
negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
negative regulation of receptor activity
positive regulation of receptor activity
negative regulation of CD8-positive, alpha-beta T cell activation

Function(s)

antigen binding
receptor binding
protein binding
beta-2-microglobulin binding
co-receptor binding
peptide antigen binding
transferrin receptor binding