s5645

• Gene Symbol: GCH1
• Gene Name: GTP cyclohydrolase 1
• Gene Aliases: DYT14, DYT5, DYT5a, GCH, GTP-CH-1, GTPCH1, HPABH4B
• Chromosome Location: Chr.14: 54842005 - 54902824 on Build GRCh38
• UniGene ID: Hs.86724
• Species: Human
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: GCH1
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_000161.2	NP_000152.1	3, 4	675
	NM_001024024.1	NP_001019195.1	3, 4	675
	NM_001024070.1	NP_001019241.1	3, 4	675
	NM_001024071.1	NP_001019242.1	3, 4	675
	XM_017021218.1	XP_016876707.1	3, 4	1107
GenBank mRNA	AY137463.1	-	3, 4	297
	AY137464.1	-	3, 4	297
	BC025415.2	-	3, 4	662	4129035
	CR536551.1	-	3, 4	514
	S43856.1	-	3, 4	581
	S44049.1	-	3, 4	488
	S44053.1	-	3, 4	581
	U19523.1	-	3, 4	662
	U66095.1	-	3, 4	658
	U66097.1	-	3, 4	667
	Z16418.1	-	3, 4	338
	Z29433.2	-	3, 4	613
	Z29434.2	-	3, 4	661

More Information

Panther Classification:

Molecular Function -

hydrolase, metabolite interconversion enzyme

Gene Ontology Categories:

Process(es)

tetrahydrobiopterin biosynthetic process
nitric oxide biosynthetic process
regulation of blood pressure
regulation of lung blood pressure
response to lipopolysaccharide
response to interferon-gamma
response to tumor necrosis factor
7,8-dihydroneopterin 3'-triphosphate biosynthetic process
vasodilation
dopamine biosynthetic process
pteridine-containing compound biosynthetic process
negative regulation of blood pressure
tetrahydrofolate biosynthetic process
response to pain
neuromuscular process controlling posture
regulation of nitric-oxide synthase activity
positive regulation of nitric-oxide synthase activity
protein homooligomerization
protein heterooligomerization
regulation of removal of superoxide radicals

Function(s)

GTP cyclohydrolase I activity
calcium ion binding
protein binding
GTP binding
zinc ion binding
GTP-dependent protein binding
protein homodimerization activity
coenzyme binding