s613 Validated

• Gene Symbol: ERBB2
• Gene Name: erb-b2 receptor tyrosine kinase 2
• Gene Aliases: CD340, HER-2, HER-2/neu, HER2, MLN 19, NEU, NGL, TKR1
• Chromosome Location: Chr.17: 39688084 - 39728662 on Build GRCh38
• UniGene ID: Hs.446352
• Species: Human
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: ERBB2
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_001005862.2	NP_001005862.1	26, 27	3367
	NM_001289936.1	NP_001276865.1	27, 28	3418
	NM_001289937.1	NP_001276866.1	23, 24	3142
	NM_004448.3	NP_004439.2	23, 24	3142
	NR_110535.1		23, 24	3205
GenBank mRNA	AK295195.1	-	27, 28	3418
	AK300321.1	-	17, 18	2316
	AK313683.1	-	23, 24	3096
	BC080193.1	-	23, 24	3103
	BC167147.1	-	23, 24	2884	100013444
	KJ534831.1	-	23, 24	2881
	M11730.1	-	23, 24	3031
	X03363.1	-	23, 24	3055

More Information

Other Species Targeted

This siRNA also targets the following transcripts in Rat: NM_017003, XM_006247245, BC061863, X03362, AY116182.

Matching Taqman Gene Expression Assay:

Hs00170433_m1

Panther Classification:

Molecular Function -

transmembrane signal receptor

Gene Ontology Categories:

Process(es)

MAPK cascade
positive regulation of protein phosphorylation
transcription, DNA-templated
protein phosphorylation
signal transduction
cell surface receptor signaling pathway
enzyme linked receptor protein signaling pathway
transmembrane receptor protein tyrosine kinase signaling pathway
peripheral nervous system development
heart development
neuromuscular junction development
motor neuron axon guidance
cell proliferation
phosphatidylinositol 3-kinase signaling
regulation of phosphatidylinositol 3-kinase signaling
peptidyl-tyrosine phosphorylation
positive regulation of cell growth
regulation of microtubule-based process
negative regulation of immature T cell proliferation in thymus
ERBB2 signaling pathway
wound healing
myelination
positive regulation of MAP kinase activity
positive regulation of GTPase activity
positive regulation of translation
regulation of angiogenesis
positive regulation of cell adhesion
positive regulation of transcription from RNA polymerase I promoter
positive regulation of transcription from RNA polymerase III promoter
protein autophosphorylation
phosphatidylinositol phosphorylation
phosphatidylinositol-mediated signaling
oligodendrocyte differentiation
positive regulation of epithelial cell proliferation
regulation of ERK1 and ERK2 cascade
cellular response to growth factor stimulus
cellular response to epidermal growth factor stimulus
positive regulation of protein targeting to membrane
regulation of cell motility

Function(s)

RNA polymerase I core binding
protein tyrosine kinase activity
transmembrane receptor protein tyrosine kinase activity
receptor signaling protein tyrosine kinase activity
transmembrane signaling receptor activity
Ras guanyl-nucleotide exchange factor activity
protein binding
ATP binding
protein C-terminus binding
growth factor binding
protein phosphatase binding
identical protein binding
ErbB-3 class receptor binding
phosphatidylinositol-4,5-bisphosphate 3-kinase activity
protein heterodimerization activity
protein dimerization activity