s70521

• Gene Symbol: Nfe2l2
• Gene Name: nuclear factor, erythroid derived 2, like 2
• Gene Aliases: AI194320, Nrf2
• Chromosome Location: Chr.2: 75675519 - 75704641 on Build GRCm38
• UniGene ID: Mm.1025
• Species: Mouse
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: Nfe2l2
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_010902.3	NP_035032.1	5	1914
GenBank mRNA	AK142347.1	-	5	1816
	AK144247.1	-	5	1788
	BC026943.1	-	5	1855	3663276
	U20532.1	-	5	1930

More Information

Other Species Targeted

This siRNA also targets the following transcripts in Rat: NM_031789, XM_006234396, XM_006234397, XM_006234398, FQ221441, and others.

Panther Classification:

Molecular Function -

basic leucine zipper transcription factor

Gene Ontology Categories:

Process(es)

transcription, DNA-templated
regulation of transcription, DNA-templated
transcription from RNA polymerase II promoter
inflammatory response
proteasomal ubiquitin-independent protein catabolic process
positive regulation of gene expression
protein ubiquitination
positive regulation of blood coagulation
endoplasmic reticulum unfolded protein response
cellular response to oxidative stress
response to endoplasmic reticulum stress
cellular response to drug
positive regulation of transcription from RNA polymerase II promoter in response to stress
positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress
PERK-mediated unfolded protein response
cellular response to glucose starvation
proteasome-mediated ubiquitin-dependent protein catabolic process
cell redox homeostasis
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
regulation of embryonic development
negative regulation of cell death
cellular response to hydrogen peroxide
cellular response to tumor necrosis factor
cellular response to fluid shear stress
cellular response to laminar fluid shear stress
negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
negative regulation of hydrogen peroxide-induced cell death
positive regulation of glutathione biosynthetic process
regulation of removal of superoxide radicals
negative regulation of endothelial cell apoptotic process
positive regulation of reactive oxygen species metabolic process

Function(s)

transcription regulatory region sequence-specific DNA binding
RNA polymerase II distal enhancer sequence-specific DNA binding
RNA polymerase II activating transcription factor binding
transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding
transcription cofactor binding
DNA binding
transcription factor activity, sequence-specific DNA binding
protein binding
protein domain specific binding
sequence-specific DNA binding
protein heterodimerization activity