s70620

• Gene Symbol: Nkx2-5
• Gene Name: NK2 homeobox 5
• Gene Aliases: Csx, Nkx-2.5, Nkx2.5, tinman
• Chromosome Location: Chr.17: 26838664 - 26844994 on Build GRCm38
• UniGene ID: Mm.41974
• Species: Mouse
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: Nkx2-5
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_008700.2	NP_032726.1	2	1474
GenBank mRNA	AK142146.1	-	2	1379
	X75415.1	-	2	1538

More Information

Panther Classification:

Molecular Function -

homeodomain transcription factor

Gene Ontology Categories:

Process(es)

negative regulation of transcription from RNA polymerase II promoter
vasculogenesis
heart looping
heart morphogenesis
outflow tract septum morphogenesis
outflow tract morphogenesis
cardiac conduction system development
atrioventricular node development
bundle of His development
Purkinje myocyte differentiation
cardiac ventricle morphogenesis
cardiac ventricle formation
right ventricular cardiac muscle tissue morphogenesis
ventricular trabecula myocardium morphogenesis
apoptotic process involved in heart morphogenesis
septum secundum development
proepicardium development
pulmonary myocardium development
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
transcription from RNA polymerase II promoter
multicellular organism development
endoderm development
heart development
adult heart development
positive regulation of cell proliferation
positive regulation of gene expression
negative regulation of cardiac muscle cell apoptotic process
positive regulation of transcription via serum response element binding
positive regulation of sodium ion transport
negative regulation of myotube differentiation
hemopoiesis
cell differentiation
BMP signaling pathway
thyroid gland development
embryonic heart tube development
negative regulation of apoptotic process
tongue development
sarcomere organization
positive regulation of neuron differentiation
positive regulation of heart contraction
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
spleen development
cardiac muscle tissue development
positive regulation of cardioblast differentiation
ventricular cardiac myofibril assembly
cardiac muscle cell differentiation
cardiac muscle tissue morphogenesis
atrial cardiac muscle cell development
ventricular cardiac muscle cell development
regulation of cardiac muscle contraction
pharyngeal system development
cardiac muscle cell proliferation
regulation of cardiac muscle cell proliferation
heart contraction
cardiac muscle contraction
canonical Wnt signaling pathway
positive regulation of transcription initiation from RNA polymerase II promoter
heart trabecula formation
ventricular septum morphogenesis
atrial septum morphogenesis
atrioventricular node cell development
atrioventricular node cell fate commitment
embryonic heart tube left/right pattern formation
cardiovascular system development
negative regulation of canonical Wnt signaling pathway
positive regulation of voltage-gated calcium channel activity

Function(s)

RNA polymerase II core promoter proximal region sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
RNA polymerase II transcription cofactor activity
transcriptional activator activity, RNA polymerase II transcription factor binding
DNA binding
chromatin binding
transcription factor activity, sequence-specific DNA binding
transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
protein binding
transcription factor binding
serum response element binding
protein homodimerization activity
histone deacetylase binding
sequence-specific DNA binding
transcription regulatory region DNA binding
protein heterodimerization activity