s71270

• Gene Symbol: Pax6
• Gene Name: paired box 6
• Gene Aliases: 1500038E17Rik, AEY11, Dey, Gsfaey11, Pax-6, Sey
• Chromosome Location: Chr.2: 105667518 - 105697364 on Build GRCm38
• UniGene ID: Mm.33870
• Species: Mouse
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: Pax6
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_001244198.1	NP_001231127.1	6	496
	NM_001244200.1	NP_001231129.1	7	708
	NM_001244201.1	NP_001231130.1	5	454
	NM_001244202.1	NP_001231131.1	5	1010
	NM_013627.5	NP_038655.1	6	1052
GenBank mRNA	AF443223.1	-	2	169
	AJ292077.1	-	5	313
	AJ307468.1	-	5	320
	AK028059.1	-	5	455
	AK032616.1	-	6	497
	AK045805.1	-	5	1011
	BC011272.1	-	6	740	4008490
	BC036957.1	-	5	450	4504106
	M77842.1	-	1	39
	X63963.1	-	6	373

More Information

Other Species Targeted

This siRNA also targets the following transcripts in Human: NM_001258463, NM_001604, NM_000280, NM_001258465, NM_001127612, and others.
This siRNA also targets the following transcripts in Rat: NM_013001, XM_006234634, XM_008762060, XM_006234633, XM_006234636, and others.

Gene Ontology Categories:

Process(es)

negative regulation of transcription from RNA polymerase II promoter
establishment of mitotic spindle orientation
blood vessel development
cell fate determination
neural crest cell migration
neuron migration
negative regulation of protein phosphorylation
positive regulation of neuroblast proliferation
epithelial cell development
lens development in camera-type eye
type B pancreatic cell differentiation
pancreatic A cell differentiation
pancreatic A cell development
transcription, DNA-templated
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
transcription from RNA polymerase II promoter
smoothened signaling pathway
multicellular organism development
axonogenesis
axon guidance
brain development
salivary gland morphogenesis
negative regulation of cell proliferation
regulation of asymmetric cell division
dorsal/ventral axis specification
anterior/posterior pattern specification
dorsal/ventral pattern formation
regulation of gene expression
positive regulation of gene expression
regulation of neuron projection development
pallium development
rhombomere morphogenesis
olfactory bulb development
oligodendrocyte cell fate specification
cerebral cortex regionalization
forebrain anterior/posterior pattern specification
forebrain dorsal/ventral pattern formation
commitment of neuronal cell to specific neuron type in forebrain
forebrain-midbrain boundary formation
regulation of transcription from RNA polymerase II promoter involved in spinal cord motor neuron fate specification
regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification
regulation of transcription from RNA polymerase II promoter involved in somatic motor neuron fate commitment
telencephalon regionalization
pituitary gland development
interkinetic nuclear migration
signal transduction involved in regulation of gene expression
cell differentiation
keratinocyte differentiation
regulation of cell migration
positive regulation of epithelial cell differentiation
forebrain development
hindbrain development
lacrimal gland development
protein localization to organelle
eye photoreceptor cell development
glucose homeostasis
positive regulation of cell fate specification
camera-type eye development
cell fate commitment
regulation of neuron differentiation
negative regulation of neuron differentiation
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
regulation of timing of cell differentiation
embryonic camera-type eye morphogenesis
astrocyte differentiation
negative regulation of epithelial cell proliferation
regulation of neurogenesis
retina development in camera-type eye
iris morphogenesis
cornea development in camera-type eye
neural precursor cell proliferation
positive regulation of glucagon secretion
insulin metabolic process
negative regulation of neural precursor cell proliferation
positive regulation of neuron migration

Function(s)

RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II core promoter sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
AT DNA binding
chromatin binding
double-stranded DNA binding
transcription factor activity, sequence-specific DNA binding
protein binding
transcription factor binding
protein kinase binding
ubiquitin protein ligase binding
histone acetyltransferase binding
sequence-specific DNA binding
transcription regulatory region DNA binding
co-SMAD binding
R-SMAD binding
HMG box domain binding