s73242

• Gene Symbol: Ryr2
• Gene Name: ryanodine receptor 2, cardiac
• Gene Aliases: 9330127I20Rik, RYR-2
• Chromosome Location: Chr.13: 11553099 - 12106945 on Build GRCm38
• UniGene ID: Mm.239871
• Species: Mouse
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: Ryr2
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_023868.2	NP_076357.2	20	2503
GenBank mRNA	AF295105.1	-	20	2004
	BC043140.1	-	19	2482
	BC059061.1	-	19	2482

More Information

Other Species Targeted

This siRNA also targets the following transcripts in Rat: NM_001191043, NM_032078, EU346200, BC167757, AB204523.

Panther Classification:

Molecular Function -

ligand-gated ion channel, scaffold/adaptor protein

Gene Ontology Categories:

Process(es)

response to hypoxia
regulation of heart rate
embryonic heart tube morphogenesis
left ventricular cardiac muscle tissue morphogenesis
cardiac muscle hypertrophy
detection of calcium ion
transport
ion transport
calcium ion transport
cellular calcium ion homeostasis
multicellular organism development
positive regulation of heart rate
regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
regulation of cardiac muscle contraction by calcium ion signaling
release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
response to muscle activity
calcium-mediated signaling
BMP signaling pathway
response to caffeine
response to magnesium ion
ion transmembrane transport
calcium-mediated signaling using intracellular calcium source
response to muscle stretch
release of sequestered calcium ion into cytosol
positive regulation of sequestering of calcium ion
regulation of cytosolic calcium ion concentration
negative regulation of cytosolic calcium ion concentration
response to calcium ion
response to redox state
transmembrane transport
regulation of cardiac muscle contraction
cardiac muscle contraction
canonical Wnt signaling pathway
cytosolic calcium ion transport
calcium ion transport into cytosol
sarcoplasmic reticulum calcium ion transport
calcium ion transmembrane transport
cellular response to caffeine
manganese ion transmembrane transport
cellular response to epinephrine stimulus
establishment of protein localization to endoplasmic reticulum
ventricular cardiac muscle cell action potential
Purkinje myocyte to ventricular cardiac muscle cell signaling
type B pancreatic cell apoptotic process
positive regulation of the force of heart contraction
regulation of AV node cell action potential
regulation of SA node cell action potential
regulation of atrial cardiac muscle cell action potential
regulation of ventricular cardiac muscle cell action potential
positive regulation of calcium-transporting ATPase activity

Function(s)

ion channel activity
ryanodine-sensitive calcium-release channel activity
calcium channel activity
calcium ion binding
protein binding
calmodulin binding
calcium-release channel activity
enzyme binding
protein kinase binding
protein kinase A catalytic subunit binding
protein kinase A regulatory subunit binding
identical protein binding
protein self-association
suramin binding
calcium-induced calcium release activity
scaffold protein binding
organic cyclic compound binding