s7520

• Gene Symbol: IRS1
• Gene Name: insulin receptor substrate 1
• Gene Aliases: HIRS-1
• Chromosome Location: Chr.2: 226731317 - 226798790 on Build GRCh38
• UniGene ID: Hs.471508
• Species: Human
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: IRS1
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_005544.2	NP_005535.1	1	580
GenBank mRNA	BC053895.1	-	1	580	6144252
	S62539.1	-	1	1548

More Information

Other Species Targeted

This siRNA also targets the following transcripts in Mouse: NM_010570, AK142242, AK045317, X69722, L24563.

Gene Ontology Categories:

Process(es)

MAPK cascade
signal transduction
positive regulation of cell proliferation
insulin receptor signaling pathway
positive regulation of glucose metabolic process
phosphatidylinositol 3-kinase signaling
regulation of phosphatidylinositol 3-kinase signaling
positive regulation of fatty acid beta-oxidation
response to insulin
cellular response to insulin stimulus
phosphatidylinositol-3-phosphate biosynthetic process
glucose homeostasis
response to peptide hormone
positive regulation of GTPase activity
positive regulation of phosphatidylinositol 3-kinase activity
positive regulation of glycogen biosynthetic process
positive regulation of glucose import
negative regulation of insulin receptor signaling pathway
positive regulation of insulin receptor signaling pathway
negative regulation of insulin secretion
phosphatidylinositol phosphorylation
insulin-like growth factor receptor signaling pathway
phosphatidylinositol-mediated signaling
positive regulation of glucose import in response to insulin stimulus

Function(s)

signal transducer activity
transmembrane receptor protein tyrosine kinase adaptor activity
protein kinase C binding
Ras guanyl-nucleotide exchange factor activity
insulin receptor binding
insulin-like growth factor receptor binding
protein binding
1-phosphatidylinositol-3-kinase activity
SH2 domain binding
phosphatidylinositol 3-kinase binding
phosphatidylinositol-4,5-bisphosphate 3-kinase activity