s7650

• Gene Symbol: JAK2
• Gene Name: Janus kinase 2
• Gene Aliases: JTK10, THCYT3
• Chromosome Location: Chr.9: 4985086 - 5128183 on Build GRCh38
• UniGene ID: Hs.656213
• Species: Human
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: JAK2
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_001322194.1	NP_001309123.1	10	1864
	NM_001322195.1	NP_001309124.1	9	1382
	NM_001322196.1	NP_001309125.1	9	1695
	NM_001322198.1	NP_001309127.1	10	1683
	NM_001322199.1	NP_001309128.1	10	1625
	NM_001322204.1	NP_001309133.1	7	1134
	NM_004972.3	NP_004963.1	10	1763
GenBank mRNA	AF005216.1	-	10	1763
	AF058925.1	-	10	1746
	AK292525.1	-	9	1382
	AK302618.1	-	7	1193
	AY973034.1	-	9	1340
	BC039695.1	-	9	1367	5556026
	BC043187.2	-	1	929

More Information

Other Species Targeted

This siRNA also targets the following transcripts in Rat: NM_031514, AJ000557, U13396.

Gene Ontology Categories:

Process(es)

MAPK cascade
activation of MAPKK activity
adaptive immune response
protein phosphorylation
apoptotic process
activation of cysteine-type endopeptidase activity involved in apoptotic process
movement of cell or subcellular component
signal transduction
enzyme linked receptor protein signaling pathway
G-protein coupled receptor signaling pathway
positive regulation of cytosolic calcium ion concentration
JAK-STAT cascade
tyrosine phosphorylation of STAT protein
STAT protein import into nucleus
mesoderm development
blood coagulation
positive regulation of cell proliferation
negative regulation of cell proliferation
intrinsic apoptotic signaling pathway in response to oxidative stress
negative regulation of cardiac muscle cell apoptotic process
positive regulation of cell-substrate adhesion
positive regulation of phosphatidylinositol 3-kinase signaling
cell migration
peptidyl-tyrosine phosphorylation
cytokine-mediated signaling pathway
negative regulation of cell-cell adhesion
actin filament polymerization
cell differentiation
erythrocyte differentiation
positive regulation of cell migration
axon regeneration
mineralocorticoid receptor signaling pathway
positive regulation of insulin secretion
response to lipopolysaccharide
positive regulation of phosphoprotein phosphatase activity
positive regulation of interleukin-1 beta production
positive regulation of tumor necrosis factor production
positive regulation of protein import into nucleus, translocation
response to hydroperoxide
tumor necrosis factor-mediated signaling pathway
response to tumor necrosis factor
histone H3-Y41 phosphorylation
intracellular signal transduction
interleukin-12-mediated signaling pathway
peptidyl-tyrosine autophosphorylation
regulation of cell proliferation
tyrosine phosphorylation of Stat3 protein
tyrosine phosphorylation of Stat5 protein
tyrosine phosphorylation of Stat1 protein
positive regulation of tyrosine phosphorylation of Stat3 protein
positive regulation of tyrosine phosphorylation of Stat5 protein
activation of JAK2 kinase activity
regulation of apoptotic process
positive regulation of DNA binding
negative regulation of DNA binding
negative regulation of neuron apoptotic process
positive regulation of GTPase activity
innate immune response
positive regulation of nitric oxide biosynthetic process
positive regulation of cell differentiation
negative regulation of heart contraction
response to antibiotic
protein autophosphorylation
platelet-derived growth factor receptor signaling pathway
regulation of inflammatory response
positive regulation of inflammatory response
positive regulation of peptidyl-tyrosine phosphorylation
positive regulation of cell activation
positive regulation of sequence-specific DNA binding transcription factor activity
positive regulation of nitric-oxide synthase biosynthetic process
interferon-gamma-mediated signaling pathway
regulation of interferon-gamma-mediated signaling pathway
growth hormone receptor signaling pathway
JAK-STAT cascade involved in growth hormone signaling pathway
positive regulation of growth hormone receptor signaling pathway
mammary gland epithelium development
response to interleukin-12
extrinsic apoptotic signaling pathway
activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway

Function(s)

protein kinase activity
protein tyrosine kinase activity
non-membrane spanning protein tyrosine kinase activity
Ras guanyl-nucleotide exchange factor activity
receptor binding
growth hormone receptor binding
interleukin-12 receptor binding
protein binding
ATP binding
protein C-terminus binding
protein kinase binding
heme binding
type 1 angiotensin receptor binding
acetylcholine receptor binding
histone kinase activity (H3-Y41 specific)
SH2 domain binding
histone binding
phosphatidylinositol 3-kinase binding
insulin receptor substrate binding
metal ion binding
peptide hormone receptor binding