s76899

• Gene Symbol: Tlr2
• Gene Name: toll-like receptor 2
• Gene Aliases: Ly105
• Chromosome Location: Chr.3: 83836272 - 83841825 on Build GRCm38
• UniGene ID: Mm.87596
• Species: Mouse
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: Tlr2
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_011905.3	NP_036035.3	3	1746
GenBank mRNA	AF124741.1	-	3	1685
	AF165189.1	-	3	1710
	AF185284.1	-	3	1700
	AF216289.1	-	3	1709
	AK005043.1	-	3	1747
	AK154504.1	-	3	1716
	AY179346.1	-	2	1561
	BC014693.1	-	3	1905	3966249

More Information

Other Species Targeted

This siRNA also targets the following transcripts in Rat: NM_198769, XM_008761102, AY151256, AY151255.

Gene Ontology Categories:

Process(es)

microglial cell activation
toll-like receptor signaling pathway
response to molecule of bacterial origin
response to molecule of fungal origin
cytokine secretion involved in immune response
immune system process
positive regulation of leukocyte migration
regulation of dendritic cell cytokine production
cell surface pattern recognition receptor signaling pathway
MyD88-dependent toll-like receptor signaling pathway
leukotriene metabolic process
inflammatory response
immune response
signal transduction
I-kappaB phosphorylation
negative regulation of cell proliferation
response to bacterium
positive regulation of Wnt signaling pathway
central nervous system myelin formation
response to bacterial lipoprotein
response to peptidoglycan
interleukin-10 production
negative regulation of interleukin-12 production
negative regulation of interleukin-17 production
positive regulation of chemokine production
positive regulation of interferon-beta production
positive regulation of interleukin-10 production
positive regulation of interleukin-12 production
positive regulation of interleukin-18 production
positive regulation of interleukin-6 production
positive regulation of interleukin-8 production
positive regulation of tumor necrosis factor production
positive regulation of toll-like receptor signaling pathway
toll-like receptor 2 signaling pathway
positive regulation of NF-kappaB import into nucleus
detection of triacyl bacterial lipopeptide
detection of diacyl bacterial lipopeptide
positive regulation of tumor necrosis factor biosynthetic process
chloramphenicol transport
negative regulation of growth of symbiont in host
innate immune response
positive regulation of nitric oxide biosynthetic process
positive regulation of transcription from RNA polymerase II promoter
nitric oxide metabolic process
positive regulation of oligodendrocyte differentiation
regulation of cytokine secretion
positive regulation of cytokine secretion
positive regulation of inflammatory response
defense response to Gram-positive bacterium
positive regulation of NF-kappaB transcription factor activity
positive regulation of nitric-oxide synthase biosynthetic process
induction by symbiont of defense-related host nitric oxide production
positive regulation of macrophage cytokine production
response to fatty acid
cellular response to bacterial lipopeptide
cellular response to lipoteichoic acid
cellular response to peptidoglycan
cellular response to diacyl bacterial lipopeptide
cellular response to triacyl bacterial lipopeptide

Function(s)

receptor activity
transmembrane signaling receptor activity
protein binding
signaling pattern recognition receptor activity
triacyl lipopeptide binding
diacyl lipopeptide binding
peptidoglycan binding
protein heterodimerization activity
lipoteichoic acid binding
lipopeptide binding