s8645 Validated

• Gene Symbol: MECP2
• Gene Name: methyl-CpG binding protein 2
• Gene Aliases: AUTSX3, MRX16, MRX79, MRXS13, MRXSL, PPMX, RS, RTS, RTT
• Chromosome Location: Chr.X: 154021800 - 154097731 on Build GRCh38
• UniGene ID: Hs.200716
• Species: Human
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: MECP2
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_001110792.1	NP_001104262.1	3	1488
	NM_001316337.1	NP_001303266.1	5	1780
	NM_004992.3	NP_004983.1	4	1612
	XM_005274682.4	XP_005274739.1	5	1686
	XM_006724819.3	XP_006724882.1	4	1363
	XM_011531166.2	XP_011529468.1	3	1499
	XM_017029533.1	XP_016885022.1	7	2112
GenBank mRNA	AB209464.1	-	3	318
	AF158180.1	-	4	1553
	AJ132917.1	-	3	1461
	AK289444.1	-	4	1587
	AY541280.1	-	3	1429
	BC011612.1	-	3	1470	3956518
	GQ203293.1	-	4	1613
	GQ203294.1	-	4	1612
	GQ203295.1	-	4	1612
	GQ896382.1	-	4	1612
	GU479943.1	-	4	1612
	GU812285.1	-	3	1387
	GU812286.1	-	3	1386
	HM020402.1	-	4	1608
	HM156732.1	-	4	1612
	HM156733.1	-	4	1612
	HQ127345.1	-	4	977
	HQ141377.1	-	3	1386
	HQ141378.1	-	4	1612
	KU178174.1	-	3	1386
	KU178175.1	-	5	1010
	KU178176.1	-	4	927
	KU178177.1	-	4	695
	KU178178.1	-	3	306
	KU178179.1	-	3	304
	KU178180.1	-	3	216
	L37298.1	-	3	1467
	X89430.1	-	2	1357
	X99686.1	-	3	1460
	Y12643.1	-	3	1450

More Information

Other Species Targeted

This siRNA also targets the following transcripts in Rat: NM_022673, XM_006229566, XM_006229567, M94064, DQ897369, and others.

Matching Taqman Gene Expression Assay:

Hs00172845_m1

Panther Classification:

Molecular Function -

DNA metabolism protein

Gene Ontology Categories:

Process(es)

negative regulation of transcription from RNA polymerase II promoter
behavioral fear response
response to hypoxia
startle response
neurological system process involved in regulation of systemic arterial blood pressure
regulation of respiratory gaseous exchange by neurological system process
inositol metabolic process
mitochondrial electron transport, ubiquinol to cytochrome c
chromatin silencing
regulation of gene expression by genetic imprinting
transcription, DNA-templated
glutamine metabolic process
cellular biogenic amine metabolic process
synapse assembly
heart development
respiratory gaseous exchange
long-term memory
locomotory behavior
protein localization
glucocorticoid metabolic process
positive regulation of cell proliferation
adult locomotory behavior
visual learning
response to radiation
pathogenesis
post-embryonic development
response to ionizing radiation
response to lead ion
dendrite development
histone methylation
histone acetylation
proprioception
sensory perception of pain
cerebellum development
ventricular system development
negative regulation of histone methylation
cardiolipin metabolic process
response to estradiol
negative regulation of histone acetylation
social behavior
neuron maturation
negative regulation of neuron apoptotic process
regulation of DNA methylation
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
phosphatidylcholine metabolic process
negative regulation of astrocyte differentiation
catecholamine secretion
positive regulation of synapse assembly
excitatory postsynaptic potential
long-term synaptic potentiation

Function(s)

four-way junction DNA binding
DNA binding
transcription factor activity, sequence-specific DNA binding
transcription corepressor activity
mRNA binding
protein binding
transcription factor binding
methyl-CpG binding
double-stranded methylated DNA binding
protein domain specific binding
chromatin DNA binding
siRNA binding
histone deacetylase binding
poly(A) RNA binding
unmethylated CpG binding
protein N-terminus binding