s8646 Validated

• Gene Symbol: MECP2
• Gene Name: methyl-CpG binding protein 2
• Gene Aliases: AUTSX3, MRX16, MRX79, MRXS13, MRXSL, PPMX, RS, RTS, RTT
• Chromosome Location: Chr.X: 154021800 - 154097731 on Build GRCh38
• UniGene ID: Hs.200716
• Species: Human
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: MECP2
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_001110792.1	NP_001104262.1	3	1657
	NM_001316337.1	NP_001303266.1	5	1949
	NM_004992.3	NP_004983.1	4	1781
	XM_005274682.4	XP_005274739.1	5	1855
	XM_006724819.3	XP_006724882.1	4	1532
	XM_011531166.2	XP_011529468.1	3	1668
	XM_017029533.1	XP_016885022.1	7	2281
GenBank mRNA	AB209464.1	-	3	487
	AF158180.1	-	4	1722
	AJ132917.1	-	3	1630
	AK289444.1	-	4	1756
	BC011612.1	-	3	1639	3956518
	BX538060.1	-	3	1647
	GQ203293.1	-	4	1782
	GQ203294.1	-	4	1781
	GQ203295.1	-	4	1783
	GQ896382.1	-	4	1781
	GU479943.1	-	4	1781
	HM020402.1	-	4	1777
	HM156732.1	-	4	1781
	HQ141378.1	-	4	1783
	HQ154629.1	-	5	1441
	L37298.1	-	3	1636
	X89430.1	-	2	1526
	Y12643.1	-	3	1619

More Information

Other Species Targeted

This siRNA also targets the following transcripts in Rat: XM_006229566, XM_006229567.
This siRNA also targets the following transcripts in Mouse: NM_001081979, NM_010788, AF158181, AK158664, AJ132922.

Matching Taqman Gene Expression Assay:

Hs00172845_m1

Panther Classification:

Molecular Function -

DNA metabolism protein

Gene Ontology Categories:

Process(es)

negative regulation of transcription from RNA polymerase II promoter
behavioral fear response
response to hypoxia
startle response
neurological system process involved in regulation of systemic arterial blood pressure
regulation of respiratory gaseous exchange by neurological system process
inositol metabolic process
mitochondrial electron transport, ubiquinol to cytochrome c
chromatin silencing
regulation of gene expression by genetic imprinting
transcription, DNA-templated
glutamine metabolic process
cellular biogenic amine metabolic process
synapse assembly
heart development
respiratory gaseous exchange
long-term memory
locomotory behavior
protein localization
glucocorticoid metabolic process
positive regulation of cell proliferation
adult locomotory behavior
visual learning
response to radiation
pathogenesis
post-embryonic development
response to ionizing radiation
response to lead ion
dendrite development
histone methylation
histone acetylation
proprioception
sensory perception of pain
cerebellum development
ventricular system development
negative regulation of histone methylation
cardiolipin metabolic process
response to estradiol
negative regulation of histone acetylation
social behavior
neuron maturation
negative regulation of neuron apoptotic process
regulation of DNA methylation
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
phosphatidylcholine metabolic process
negative regulation of astrocyte differentiation
catecholamine secretion
positive regulation of synapse assembly
excitatory postsynaptic potential
long-term synaptic potentiation

Function(s)

four-way junction DNA binding
DNA binding
transcription factor activity, sequence-specific DNA binding
transcription corepressor activity
mRNA binding
protein binding
transcription factor binding
methyl-CpG binding
double-stranded methylated DNA binding
protein domain specific binding
chromatin DNA binding
siRNA binding
histone deacetylase binding
poly(A) RNA binding
unmethylated CpG binding
protein N-terminus binding