1-Methylpiperazine, 98+%

Description

CAS: 109-01-3 | C5H12N2 | 100.165 g/mol

1-Methylpiperazine is used in the preparation of 2-(4-methyl-1-piperazinylmethyl)acrylophenone. It is involved in the preparation of 1-(4-methoxy-phenyl)-4-methyl-piperazine by reacting with 1-chloro-4-methoxy-benzene. It acts as an intermediate in the synthesis of active pharmaceutical ingredients like ofloxacin, rifampicin, clozapine, sildenafil, trifluoperazine and zopiclone. Further, it is used as a mimic template in the preparation of molecularly imprinted microspheres. In addition to this, it is used in the generation of difunctional strong anion-exchange stationary phase from a 1,4-diazacyclohexane derivative.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
1-Methylpiperazine is used in the preparation of 2-(4-methyl-1-piperazinylmethyl)acrylophenone. It is involved in the preparation of 1-(4-methoxy-phenyl)-4-methyl-piperazine by reacting with 1-chloro-4-methoxy-benzene. It acts as an intermediate in the synthesis of active pharmaceutical ingredients like ofloxacin, rifampicin, clozapine, sildenafil, trifluoperazine and zopiclone. Further, it is used as a mimic template in the preparation of molecularly imprinted microspheres. In addition to this, it is used in the generation of difunctional strong anion-exchange stationary phase from a 1,4-diazacyclohexane derivative.

Solubility
Miscible with water and methanol.

Notes
Hygroscopic. Moisture sensitive. Incompatible with acids, acid chlorides, acid anhydrides, strong oxidizing agents and carbon dioxide.

Specifications

Chemical Identifiers

• CAS: 109-01-3
• Molecular Formula: C5H12N2
• Molecular Weight (g/mol): 100.165
• MDL Number: MFCD00005966
• InChI Key: PVOAHINGSUIXLS-UHFFFAOYSA-N
• Synonym: n-methylpiperazine, piperazine, 1-methyl, 4-methylpiperazine, 1-methyl-piperazine, n-methyl piperazine, 1-methyl piperazine, methylpiperazine, n-methyl-piperazine, n-methylpiperazin, 1-methylpyperazine
• PubChem CID: 53167
• IUPAC Name: 1-methylpiperazine
• SMILES: CN1CCNCC1

• Melting Point: -6°C
• Density: 0.903
• Boiling Point: 137°C to 139°C
• Flash Point: 34°C (93°F)
• Odor: Amine-like
• Refractive Index: 1.4655
• Quantity: 100 mL
• UN Number: UN2734
• Beilstein: 102724
• Sensitivity: Air Sensitive
• Solubility Information: Miscible with water and methanol.
• Formula Weight: 100.17
• Percent Purity: ≥98%
• Chemical Name or Material: 1-Methylpiperazine

Safety and Handling

Hazard Category	H226-H302+H312+H332-H314-H317-H335
Hazard Statement	GHS H Statement H331-H314-H318-H226-H302-H312 Toxic if inhaled. Causes severe skin burns and eye damage. Causes serious eye damage. Flammable liquid and vapor. Harmful if swallowed. Harmful in contact with skin.
Precautionary Statement	P210-P233-P235-P240-P241-P242-P243-P260-P264b-P270-P271-P272-P280-P303+P361+P353-P304+P340-P305+P351+P338-P310-P330-P331-P333+P313-P363-P370+P378q-P501c
DOTInformation	Transport Hazard Class: 8; Packing Group: II; Proper Shipping Name: AMINES, LIQUID, CORROSIVE, FLAMMABLE, N.O.S.
EINECSNumber	203-639-5
RTECSNumber	TM1225000
TSCA	Yes
Recommended Storage	Ambient temperatures; Store under Argon

SDS

RUO – Research Use Only