1-Trimethylsilylmethanol, 95%

Description

CAS: 3219-63-4 | C4H12OSi | 104.224 g/mol

1-Trimethylsilylmethanol is used as nucleophile to resolve the racemate obtained from enantioselective esterification of naproxen (2-(6-methoxy-2-naphthyl) propionic acid) by lipases. It was also used as a nucleophilic hydroxymethylation agent.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
1-Trimethylsilylmethanol is used as nucleophile to resolve the racemate obtained from enantioselective esterification of naproxen (2-(6-methoxy-2-naphthyl) propionic acid) by lipases. It was also used as a nucleophilic hydroxymethylation agent.

Solubility
Fully miscible in water.

Notes
Store at 4°C. Incompatible with oxidizing agents. Store in cool place. Keep container tightly closed in a dry and well-ventilated place.

Specifications

Chemical Identifiers

• CAS: 3219-63-4
• Molecular Formula: C4H12OSi
• Molecular Weight (g/mol): 104.224
• MDL Number: MFCD00004596
• InChI Key: ZQKNBDOVPOZPLY-UHFFFAOYSA-N
• Synonym: trimethylsilyl methanol, 1-trimethylsilylmethanol, hydroxymethyltrimethylsilane, methanol, trimethylsilyl, silane, hydroxymethyl trimethyl, hydroxymethyl trimethylsilane, trimethylhydroxymethylsilane, methanol, 1-trimethylsilyl, trimethylsilyl-methanol, acmc-209hrr
• PubChem CID: 76692
• IUPAC Name: trimethylsilylmethanol
• SMILES: C[Si](C)(C)CO

• Boiling Point: 121°C to 122°C
• Quantity: 5 g
• UN Number: UN1993
• Beilstein: 1731486
• Flash Point: 31°C (87°F)
• Solubility Information: Fully miscible in water.
• Formula Weight: 104.23
• Percent Purity: ≥98%
• Refractive Index: 1.419
• Density: 0.827
• Chemical Name or Material: 1-Trimethylsilylmethanol

Safety and Handling

Hazard Category	H226
Hazard Statement	GHS H Statement H226 Flammable liquid and vapor.
Precautionary Statement	P210-P233-P240-P241-P242-P243-P280-P303+P361+P353-P370+P378q-P501c
DOTInformation	Transport Hazard Class: 3; Packing Group: III; Proper Shipping Name: FLAMMABLE LIQUIDS, N.O.S.
EINECSNumber	221-746-5
RTECSNumber	PC4100000
TSCA	Yes
Recommended Storage	Ambient temperatures

SDS

RUO – Research Use Only