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17-AAG, Tocris Bioscience™ Available on GSA/VA Contract for Federal Government customers only.

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Quantity:
1mg
This item is not returnable. View return policy
75747-14-7
C31H43N3O8
585.698
AYUNIORJHRXIBJ-MKJFUHJFSA-N
17-aag
133688938
[(3S,5R,6S,7R,8Z,11R,14E)-6-hydroxy-5,11-dimethoxy-3,7,9,15-tetramethyl-16,20,22-trioxo-21-(prop-2-enylamino)-17-azabicyclo[16.3.1]docosa-1(21),8,12,14,18-pentaen-10-yl] carbamate
CC1CC(C(C(C=C(C(C(C=CC=C(C(=O)NC2=CC(=O)C(=C(C1)C2=O)NCC=C)C)OC)OC(=O)N)C)C)O)OC
This item is not returnable. View return policy
75747-14-7
C31H43N3O8
585.698
AYUNIORJHRXIBJ-MKJFUHJFSA-N
17-aag
133688938
[(3S,5R,6S,7R,8Z,11R,14E)-6-hydroxy-5,11-dimethoxy-3,7,9,15-tetramethyl-16,20,22-trioxo-21-(prop-2-enylamino)-17-azabicyclo[16.3.1]docosa-1(21),8,12,14,18-pentaen-10-yl] carbamate
CC1CC(C(C(C=C(C(C(C=CC=C(C(=O)NC2=CC(=O)C(=C(C1)C2=O)NCC=C)C)OC)OC(=O)N)C)C)O)OC

Description

Selective Hsp90 inhibitor

Inhibitor of heat shock protein 90 (Hsp90) chaperone activity, and an analog of geldanamycin (Cat. No. 1368). Subsequently inhibits the activity of oncogenic proteins such as p185erbB-2 (IC50 = 31 nM), N-ras, Ki-ras and c-Akt. Antitumor in vivo. Also protects neuroprogenitor cells against stress-induced apoptosis at low concentrations (10 nM) in vitro.

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Quantity 1mg
Formula Weight 585.7
Percent Purity >98%
Chemical Name or Material 17-AAG

Safety and Handling

Recommended Storage : Desiccate at -20°C