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17-DMAG hydrochloride, Tocris Bioscience™

Catalog No. 26101
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26-101 1 mg
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Catalog No. 26-101 Supplier R&D Systems Supplier No. 2610/1
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Description

Water-soluble Hsp90 inhibitor

Water-soluble analog of 17-AAG (Cat. No. 1515) and geldanamycin (Cat. No. 1368). Binds the ATP binding site of Hsp90 and inhibits its chaperone activity. Displays more potent antitumor activity than 17-AAG (mean GI50 values are 53 and 123 nM for 17-DMAG and 17-AAG respectively).

Chemical Identifiers

CAS 467214-21-7
Molecular Formula C32H49ClN4O8
Molecular Weight (g/mol) 653.214
InChI Key DFSYBWLNYPEFJK-ZOKRJHFSSA-N
Synonym 17-Demethoxy-17-[[2-(dimethylamino)ethyl]amino]geldanamycin hydrochloride
PubChem CID 131954774
IUPAC Name [(3R,5S,6R,7S,8E,10S,11S)-21-[2-(dimethylamino)ethylamino]-6-hydroxy-5,11-dimethoxy-3,7,9,15-tetramethyl-16,20,22-trioxo-17-azabicyclo[16.3.1]docosa-1(21),8,12,14,18-pentaen-10-yl] carbamate;hydrochloride
SMILES CC1CC(C(C(C=C(C(C(C=CC=C(C(=O)NC2=CC(=O)C(=C(C1)C2=O)NCCN(C)C)C)OC)OC(=O)N)C)C)O)OC.Cl

Specifications

Quantity 1 mg
Formula Weight 653.21
Percent Purity >99%
Chemical Name or Material 17-DMAG hydrochloride

Safety and Handling

Recommended Storage Desiccate at -20°C
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