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  5. Tocris Bioscience™ 1A-116

Tocris Bioscience™ 1A-116
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Catalog No. 670150
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67-015-0 50 mg
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Catalog No. 67-015-0 Supplier Tocris Bioscience™ Supplier No. 6701/50
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Description

Rac1 inhibitor; blocks Rac1-P-Rex1 interaction

1A-116 is a Rac1 inhibitor. Reduces intracellular Rac1-GTP levels and blocks Rac1-P-Rex1 interaction in vitro. Exhibits no effect on GTPase activity of closely related Cdc42. Displays antiproliferative, anti-invasive and pro-apoptotic activity in several cancer cell lines. Exhibits antimetastatic activity in vivo. Also restores antiproliferative effects of Tamoxifen (Cat. No. 6342) in resistant breast cancer cell.

Specifications

Chemical Name or Material N-(3,5-Dimethylphenyl)-N'-[2-(trifluoromethyl)phenyl]guanidine
CAS 1430208-73-3
Quantity 50 mg
Molecular Formula C16H16F3N3
Formula Weight 307.31
Product Type Inhibitor
Purity 98%
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