2-Amino-4,6-dichloropyrimidine, 98%

Description

CAS: 56-05-3 | C4H3Cl2N3 | 163.989 g/mol

Microwave-assisted synthesis of pyrazolo [3, 4-d] pyrimidines from 2-amino-4, 6-dichloropyrimidine-5-carbaldehyde is under solvent-free conditions. A series of 6-alkynyl-2,4-diaminopyrimidine derivatives bearing various substituents at alkynyl moiety was prepared by the Sonogashira cross-coupling reaction of 2,4-diamino-6-iodopyrimidine using Pd(PPh3)2Cl2 as catalyst.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
Microwave-assisted synthesis of pyrazolo [3, 4-d] pyrimidines from 2-amino-4, 6-dichloropyrimidine-5-carbaldehyde is under solvent-free conditions. A series of 6-alkynyl-2,4-diaminopyrimidine derivatives bearing various substituents at alkynyl moiety was prepared by the Sonogashira cross-coupling reaction of 2,4-diamino-6-iodopyrimidine using Pd(PPh3)2Cl2 as catalyst.

Solubility
Insoluble in water, soluble in acetone, two monomer (VCM) and thermal toluene.

Notes
Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Store away from strong oxidizing agents.

Specifications

Chemical Identifiers

• CAS: 56-05-3
• Molecular Formula: C4H3Cl2N3
• Molecular Weight (g/mol): 163.989
• MDL Number: MFCD00006090
• InChI Key: JPZOAVGMSDSWSW-UHFFFAOYSA-N
• Synonym: 2-amino-4,6-dichloropyrimidine, 4,6-dichloro-2-pyrimidinamine, 2-pyrimidinamine, 4,6-dichloro, 4,6-dichloropyrimidin-2-ylamine, ccris 7460, 4,6-dichloro-pyrimidin-2-ylamine, pyrimidine, 2-amino-4,6-dichloro, 2-amino-4,6-dichloro pyrimidine, 4,6-dichloropyrimidine-2-ylamine, zlchem 351
• PubChem CID: 65522
• IUPAC Name: 4,6-dichloropyrimidin-2-amine
• SMILES: C1=C(N=C(N=C1Cl)N)Cl

• Melting Point: 218°C to 222°C
• Quantity: 100 g
• Beilstein: 118454
• Solubility Information: Insoluble in water,soluble in acetone,two monomer (VCM) and thermal toluene.
• Formula Weight: 164
• Percent Purity: 98%
• Chemical Name or Material: 2-Amino-4,6-dichloropyrimidine

Safety and Handling

Hazard Category	H315-H319-H335
Hazard Statement	GHS H Statement H315-H319-H335 Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Precautionary Statement	P261-P264b-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P362-P501c
EINECSNumber	200-253-9
RTECSNumber	UV6260485
TSCA	Yes
Recommended Storage	Ambient temperatures

SDS

RUO – Research Use Only