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Apexbio Technology LLC 2-APB(Synonyms: 2-Aminoethoxydiphenyl borate, 2-Aminoethyl diphenylborinate, 2-Aminoethoxydiphenylborane), 10mM (in 1mL DMSO), CAS: 524-95-8.
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Supplier:  Apexbio Technology LLC B66435.1

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2-APB (CAS 524-95-8) is a cell-permeable antagonist of Ins(1 4 5)P3-induced calcium release It inhibits calcium mobilization mediated by the intracellular IP3 receptor (IP3R) an essential component in Ca2 signaling events such as calcium oscillations and waves In rat cerebellar microsomes 2-APB inhibits Ins(1 4 5)P3-induced Ca2 release with an IC50 of 42 M Additionally it blocks TRPC channels including TRPC3 TRPC5 (IC50 20 M in HEK-293 cells) and TRPC6 2-APB is widely utilized in research focusing on intracellular calcium dynamics channel modulation studies and oxidative stress-related cell injury

Catalog No. 50-115-2604


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