2-Methoxyethoxymethyl chloride, 94%

Description

CAS: 3970-21-6 | C4H9ClO2 | 124.56 g/mol

2-Methoxyethoxymethyl chloride, is used as selectively cleaved under aprotic conditions in the presence of a wide range of OH-protected reagents. It is used as an OH-protecting reagent. An examples of the target molecule MEM Chloride is the side chain of roxithromycin. It is also used in the protection of the OH groups in serine and threonine during peptide synthesis. Some of the other applications include have the ability to coordinate to metals, which is thought to accelerate the cleavage by Lewis acids. The chelating ability of the MEM ether also makes it useful as a stereodirecting group in organometallic reactions, first noted in the stereo controlled addition of ?-methoxyvinyllithium to a carbonyl in the synthesis of taxusin.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
2-Methoxyethoxymethyl chloride, is used as selectively cleaved under aprotic conditions in the presence of a wide range of OH-protected reagents. It is used as an OH-protecting reagent. An examples of the target molecule MEM Chloride is the side chain of roxithromycin. It is also used in the protection of the OH groups in serine and threonine during peptide synthesis. Some of the other applications include have the ability to coordinate to metals, which is thought to accelerate the cleavage by Lewis acids. The chelating ability of the MEM ether also makes it useful as a stereodirecting group in organometallic reactions, first noted in the stereo controlled addition of ɑ-methoxyvinyllithium to a carbonyl in the synthesis of taxusin.

Solubility
It hydrolyzes with water.

Notes
Moisture, Heat, water Sensitive. Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Keep away from oxidizing agents. Stable under recommended storage conditions.

Specifications

Chemical Identifiers

• CAS: 3970-21-6
• Molecular Formula: C4H9ClO2
• Molecular Weight (g/mol): 124.56
• MDL Number: MFCD00000888
• InChI Key: BIAAQBNMRITRDV-UHFFFAOYSA-N
• Synonym: 2-methoxyethoxymethyl chloride, 1-chloromethoxy-2-methoxyethane, ethane, 1-chloromethoxy-2-methoxy, mem chloride, methoxyethoxymethyl chloride, mem-chloride, 1-chloro-2,5-dioxahexane, 2-methoxyethoxy methyl chloride, beta-methoxyethoxymethyl chloride, .beta.-methoxyethoxymethyl chloride
• PubChem CID: 77590
• IUPAC Name: 1-(chloromethoxy)-2-methoxyethane
• SMILES: COCCOCCl

• Density: 1.094
• Boiling Point: 50°C to 52°C (13 mmHg)
• Flash Point: 54°C (129°F)
• Refractive Index: 1.427
• Linear Formula: CH₃O(CH₂)₂OCH₂Cl
• Quantity: 5 g
• UN Number: UN1992
• Beilstein: 1900576
• Sensitivity: Moisture sensitive
• Solubility Information: It hydrolyzes with water.
• Formula Weight: 124.57
• Percent Purity: 94%
• Chemical Name or Material: 2-Methoxyethoxymethyl chloride

Safety and Handling

Hazard Category	H226-H302+H332-H315-H319-H335-H350
Hazard Statement	GHS H Statement H350-H226-H315-H319-H335 May cause cancer. Flammable liquid and vapor. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Precautionary Statement	P201-P202-P210-P233-P235-P240-P241-P242-P243-P261-P264b-P270-P271-P280i-P281-P301+P312-P303+P361+P353-P304+P340-P305+P351+P338-P308+P313-P330-P332+P313-P363-P370+P378q-P501c
DOTInformation	Transport Hazard Class: 3; Packing Group: III; Proper Shipping Name: FLAMMABLE LIQUIDS, TOXIC, N.O.S.
EINECSNumber	223-589-8
TSCA	Yes
Recommended Storage	Store at -20°C; Store under Nitrogen

SDS

RUO – Research Use Only